Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in channel catfish

S. M. Plakas, P. M. Loveland, G. S. Bailey, Vicki Suzette Blazer, G. L. Wilson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The pharmacokinetics, tissue distribution and excretion of 14C-labelled aflatoxin B1 (AFB1) were examined after oral administration (250 μg/kg body weight) in channel catfish (Ictalurus punctatus). Plasma concentrations of parent AFB1 were best described by a one-compartment pharmacokinetic model, in which peak plasma concentration (503 ppb) occurred at 4.1 hr after dosing. The absorption and elimination half-lives were 1.5 and 3.7 hr, respectively. AFB1 was highly bound (95%) to plasma proteins. Concentrations of 14C (in AFB1 equivalents) measured in the tissues were highest at 4 hr, ranging from 596 ppb in the plasma to 40 ppb in the muscle. AFB1 residues were rapidly depleted; at 24 hr the concentrations in the plasma and muscle were 32 and <5 ppb, respectively. Concentrations in the bile exceeded 2000 ppb (at 24 hr), whereas the highest concentration in the urine was 51 ppb (4-6-hr collection interval). Renal and biliary excretion accounted for <5% of the administered dose, indicating incomplete absorption. Pharmacokinetic modelling and tissue data demonstrate a very low potential for the accumulation of AFB1 and its metabolites in the edible flesh of channel catfish through the consumption of AFB1-contaminated feed.

Original languageEnglish (US)
Pages (from-to)805-808
Number of pages4
JournalFood and Chemical Toxicology
Volume29
Issue number12
DOIs
StatePublished - Jan 1 1991

Fingerprint

Ictaluridae
Aflatoxin B1
aflatoxin B1
Ictalurus punctatus
oral administration
Oral Administration
excretion
Tissue
Pharmacokinetics
pharmacokinetics
Plasmas
Muscle
Muscles
muscles
feed contamination
administered dose
tissue distribution
Tissue Distribution
bile
Metabolites

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

Plakas, S. M. ; Loveland, P. M. ; Bailey, G. S. ; Blazer, Vicki Suzette ; Wilson, G. L. / Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in channel catfish. In: Food and Chemical Toxicology. 1991 ; Vol. 29, No. 12. pp. 805-808.
@article{18392965765a46e7b432458d94a2f581,
title = "Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in channel catfish",
abstract = "The pharmacokinetics, tissue distribution and excretion of 14C-labelled aflatoxin B1 (AFB1) were examined after oral administration (250 μg/kg body weight) in channel catfish (Ictalurus punctatus). Plasma concentrations of parent AFB1 were best described by a one-compartment pharmacokinetic model, in which peak plasma concentration (503 ppb) occurred at 4.1 hr after dosing. The absorption and elimination half-lives were 1.5 and 3.7 hr, respectively. AFB1 was highly bound (95{\%}) to plasma proteins. Concentrations of 14C (in AFB1 equivalents) measured in the tissues were highest at 4 hr, ranging from 596 ppb in the plasma to 40 ppb in the muscle. AFB1 residues were rapidly depleted; at 24 hr the concentrations in the plasma and muscle were 32 and <5 ppb, respectively. Concentrations in the bile exceeded 2000 ppb (at 24 hr), whereas the highest concentration in the urine was 51 ppb (4-6-hr collection interval). Renal and biliary excretion accounted for <5{\%} of the administered dose, indicating incomplete absorption. Pharmacokinetic modelling and tissue data demonstrate a very low potential for the accumulation of AFB1 and its metabolites in the edible flesh of channel catfish through the consumption of AFB1-contaminated feed.",
author = "Plakas, {S. M.} and Loveland, {P. M.} and Bailey, {G. S.} and Blazer, {Vicki Suzette} and Wilson, {G. L.}",
year = "1991",
month = "1",
day = "1",
doi = "10.1016/0278-6915(91)90106-H",
language = "English (US)",
volume = "29",
pages = "805--808",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",
number = "12",

}

Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in channel catfish. / Plakas, S. M.; Loveland, P. M.; Bailey, G. S.; Blazer, Vicki Suzette; Wilson, G. L.

In: Food and Chemical Toxicology, Vol. 29, No. 12, 01.01.1991, p. 805-808.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in channel catfish

AU - Plakas, S. M.

AU - Loveland, P. M.

AU - Bailey, G. S.

AU - Blazer, Vicki Suzette

AU - Wilson, G. L.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The pharmacokinetics, tissue distribution and excretion of 14C-labelled aflatoxin B1 (AFB1) were examined after oral administration (250 μg/kg body weight) in channel catfish (Ictalurus punctatus). Plasma concentrations of parent AFB1 were best described by a one-compartment pharmacokinetic model, in which peak plasma concentration (503 ppb) occurred at 4.1 hr after dosing. The absorption and elimination half-lives were 1.5 and 3.7 hr, respectively. AFB1 was highly bound (95%) to plasma proteins. Concentrations of 14C (in AFB1 equivalents) measured in the tissues were highest at 4 hr, ranging from 596 ppb in the plasma to 40 ppb in the muscle. AFB1 residues were rapidly depleted; at 24 hr the concentrations in the plasma and muscle were 32 and <5 ppb, respectively. Concentrations in the bile exceeded 2000 ppb (at 24 hr), whereas the highest concentration in the urine was 51 ppb (4-6-hr collection interval). Renal and biliary excretion accounted for <5% of the administered dose, indicating incomplete absorption. Pharmacokinetic modelling and tissue data demonstrate a very low potential for the accumulation of AFB1 and its metabolites in the edible flesh of channel catfish through the consumption of AFB1-contaminated feed.

AB - The pharmacokinetics, tissue distribution and excretion of 14C-labelled aflatoxin B1 (AFB1) were examined after oral administration (250 μg/kg body weight) in channel catfish (Ictalurus punctatus). Plasma concentrations of parent AFB1 were best described by a one-compartment pharmacokinetic model, in which peak plasma concentration (503 ppb) occurred at 4.1 hr after dosing. The absorption and elimination half-lives were 1.5 and 3.7 hr, respectively. AFB1 was highly bound (95%) to plasma proteins. Concentrations of 14C (in AFB1 equivalents) measured in the tissues were highest at 4 hr, ranging from 596 ppb in the plasma to 40 ppb in the muscle. AFB1 residues were rapidly depleted; at 24 hr the concentrations in the plasma and muscle were 32 and <5 ppb, respectively. Concentrations in the bile exceeded 2000 ppb (at 24 hr), whereas the highest concentration in the urine was 51 ppb (4-6-hr collection interval). Renal and biliary excretion accounted for <5% of the administered dose, indicating incomplete absorption. Pharmacokinetic modelling and tissue data demonstrate a very low potential for the accumulation of AFB1 and its metabolites in the edible flesh of channel catfish through the consumption of AFB1-contaminated feed.

UR - http://www.scopus.com/inward/record.url?scp=0026326043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026326043&partnerID=8YFLogxK

U2 - 10.1016/0278-6915(91)90106-H

DO - 10.1016/0278-6915(91)90106-H

M3 - Article

C2 - 1765324

AN - SCOPUS:0026326043

VL - 29

SP - 805

EP - 808

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

IS - 12

ER -