Tissue-Engineered Peripheral Nerve Guide Fabrication Techniques

Dianna Y. Nguyen, Richard T. Tran, Francesco Costanzo, Jian Yang

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

The clinical need for readily available and viable conduits to circumvent the use of nerve autografts has driven research to the development of biodegradable tissue-engineered nerve guides (TENGs) to bridge and restore the function of transected peripheral nerves. In the search for an ideal TENG, researchers have introduced increasingly more sophisticated fabrication techniques in combination with a variety of biomaterials to produce organized porous structures conducive to nerve regeneration and functional recovery. The intent of this chapter is to delineate the TENG fabrication techniques that have been studied to enhance the regenerative effectiveness of critically sized peripheral nerve defects. In addition, important design criteria, biomaterial options, and new perspectives on future technologies toward the development of clinically viable solutions are discussed.

Original languageEnglish (US)
Title of host publicationPain, Treatment, Injury, Disease and Future Directions
PublisherElsevier
Pages971-992
Number of pages22
Volume2
ISBN (Electronic)9780128026953
ISBN (Print)9780128026533
DOIs
StatePublished - Apr 23 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Nguyen, D. Y., Tran, R. T., Costanzo, F., & Yang, J. (2015). Tissue-Engineered Peripheral Nerve Guide Fabrication Techniques. In Pain, Treatment, Injury, Disease and Future Directions (Vol. 2, pp. 971-992). Elsevier. https://doi.org/10.1016/B978-0-12-802653-3.00109-3