Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers

Adam Bleier Glick, Stuart H. Yuspa

Research output: Contribution to journalReview article

34 Scopus citations


Neoplastic cells at various stages of tumor progression may remain dormant for many years. The suppression of the neoplastic phenotype and tumor outgrowth depends on close contact of neoplastic cells with surrounding normal cells. This review examines the nature of these contacts primarily in models for skin cancer induction. Junctional complexes, membrane associated growth factors and their receptors, and paracrine mechanisms likely contribute to this state of tumor cell dormancy. Understanding these mechanisms will be important in primary cancer prevention and for counteracting recurrences in cancer survivors.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalSeminars in Cancer Biology
Issue number2
StatePublished - Apr 1 2005


All Science Journal Classification (ASJC) codes

  • Cancer Research

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