TLR-mediated cell signaling by malaria GPIs

Research output: Contribution to journalReview article

92 Citations (Scopus)

Abstract

Proinflammatory responses to malaria have crucial roles in controlling parasite growth and disease pathogenesis. The glycosylphosphatidylinositol (GPI) of Plasmodium falciparum is thought to be an important factor in the induction of proinflammatory responses. The GPI induces host cellular responses mainly through Toll-like receptor (TLR)2/MyD88-mediated signaling. Knowledge of the parasite-host factors involved in activating and regulating innate immune responses and of the associated signaling mechanisms is likely to provide insights into the modulation of parasite-specific adaptive immunity and offer targets for the development of novel therapeutics or a vaccine for malaria. This article focuses on the malaria GPI-mediated cell-signaling mechanisms.

Original languageEnglish (US)
Pages (from-to)596-604
Number of pages9
JournalTrends in Parasitology
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2007

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Glycosylphosphatidylinositols
Toll-Like Receptors
Malaria
Parasites
Malaria Vaccines
Toll-Like Receptor 2
Adaptive Immunity
Plasmodium falciparum
Innate Immunity
Growth
Therapeutics

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

Cite this

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title = "TLR-mediated cell signaling by malaria GPIs",
abstract = "Proinflammatory responses to malaria have crucial roles in controlling parasite growth and disease pathogenesis. The glycosylphosphatidylinositol (GPI) of Plasmodium falciparum is thought to be an important factor in the induction of proinflammatory responses. The GPI induces host cellular responses mainly through Toll-like receptor (TLR)2/MyD88-mediated signaling. Knowledge of the parasite-host factors involved in activating and regulating innate immune responses and of the associated signaling mechanisms is likely to provide insights into the modulation of parasite-specific adaptive immunity and offer targets for the development of novel therapeutics or a vaccine for malaria. This article focuses on the malaria GPI-mediated cell-signaling mechanisms.",
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TLR-mediated cell signaling by malaria GPIs. / Gowda, Channe.

In: Trends in Parasitology, Vol. 23, No. 12, 01.12.2007, p. 596-604.

Research output: Contribution to journalReview article

TY - JOUR

T1 - TLR-mediated cell signaling by malaria GPIs

AU - Gowda, Channe

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N2 - Proinflammatory responses to malaria have crucial roles in controlling parasite growth and disease pathogenesis. The glycosylphosphatidylinositol (GPI) of Plasmodium falciparum is thought to be an important factor in the induction of proinflammatory responses. The GPI induces host cellular responses mainly through Toll-like receptor (TLR)2/MyD88-mediated signaling. Knowledge of the parasite-host factors involved in activating and regulating innate immune responses and of the associated signaling mechanisms is likely to provide insights into the modulation of parasite-specific adaptive immunity and offer targets for the development of novel therapeutics or a vaccine for malaria. This article focuses on the malaria GPI-mediated cell-signaling mechanisms.

AB - Proinflammatory responses to malaria have crucial roles in controlling parasite growth and disease pathogenesis. The glycosylphosphatidylinositol (GPI) of Plasmodium falciparum is thought to be an important factor in the induction of proinflammatory responses. The GPI induces host cellular responses mainly through Toll-like receptor (TLR)2/MyD88-mediated signaling. Knowledge of the parasite-host factors involved in activating and regulating innate immune responses and of the associated signaling mechanisms is likely to provide insights into the modulation of parasite-specific adaptive immunity and offer targets for the development of novel therapeutics or a vaccine for malaria. This article focuses on the malaria GPI-mediated cell-signaling mechanisms.

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