To the Rescue: The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks

George Lucian Moldovan, Alan D. D'Andrea

Research output: Contribution to journalShort survey

15 Scopus citations

Abstract

DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.

Original languageEnglish (US)
Pages (from-to)5-6
Number of pages2
JournalCancer Cell
Volume22
Issue number1
DOIs
StatePublished - Jul 10 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cell Biology
  • Cancer Research

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