To the Rescue

The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks

George-Lucian Moldovan, Alan D. D'Andrea

Research output: Contribution to journalShort survey

14 Citations (Scopus)

Abstract

DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.

Original languageEnglish (US)
Pages (from-to)5-6
Number of pages2
JournalCancer Cell
Volume22
Issue number1
DOIs
StatePublished - Jul 10 2012

Fingerprint

Fanconi Anemia
Genomic Instability
S Phase
DNA Damage
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

@article{dba6ae959f1d49fd99567d72713ce0e1,
title = "To the Rescue: The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks",
abstract = "DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.",
author = "George-Lucian Moldovan and D'Andrea, {Alan D.}",
year = "2012",
month = "7",
day = "10",
doi = "10.1016/j.ccr.2012.06.006",
language = "English (US)",
volume = "22",
pages = "5--6",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "1",

}

To the Rescue : The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks. / Moldovan, George-Lucian; D'Andrea, Alan D.

In: Cancer Cell, Vol. 22, No. 1, 10.07.2012, p. 5-6.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - To the Rescue

T2 - The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks

AU - Moldovan, George-Lucian

AU - D'Andrea, Alan D.

PY - 2012/7/10

Y1 - 2012/7/10

N2 - DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.

AB - DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.

UR - http://www.scopus.com/inward/record.url?scp=84863730084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863730084&partnerID=8YFLogxK

U2 - 10.1016/j.ccr.2012.06.006

DO - 10.1016/j.ccr.2012.06.006

M3 - Short survey

VL - 22

SP - 5

EP - 6

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 1

ER -