Tolerant, growing cells from nutrient shifts are not persister cells

Jun Seob Kim, Thomas K. Wood

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and growing cell populations (e.g., as a result of nutrient shifts) and attributing the phenotypes that they discern to persister cells while other labs are studying dormant cells. We argue here that the metabolically active cell population should more accurately be considered tolerant cells, while the dormant cells are the true persister population.

Original languageEnglish (US)
Article numbere00354-17
JournalmBio
Volume8
Issue number2
DOIs
StatePublished - Mar 1 2017

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Virology

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