Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis

Paul B. Mann, Mary J. Kennett, Eric T. Harvill

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Bordetellae are important respiratory pathogens that cause pertussis (whooping cough) in humans and analogous diseases in domestic and wild animals. Immunity to Bordetella is poorly understood, in particular the early innate immune responses that contribute to inflammation, pathology, and the subsequent generation of adaptive immunity. Using B. bronchiseptica, which naturally infects mice, we show that Toll-like receptor-4 (TLR4) is required for cytokine responses to this pathogen's lipopolysaccharide (LPS) and that TLR4 deficiency results in impaired cytokine responses in vitro and in vivo. TLR4-deficient mice rapidly succumb following inoculation with as few as 1000 organisms, indicating that TLR4 is critical to innate host defense against bordetellosis.

Original languageEnglish (US)
Pages (from-to)833-836
Number of pages4
JournalJournal of Infectious Diseases
Volume189
Issue number5
DOIs
StatePublished - Mar 1 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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