Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa

Michèle R. Prinsep, Gregory M.L. Patterson, Linda K. Larsen, Charles D. Smith

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Two new porphinoids, tolyporphins J (1) and K (2), have been isolated from the terrestrial cyanobacterium, Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The activities of tolyporphins J and K in cell sensitization and drug accumulation assays for multidrug resistance (MDR) reversal were compared with those of tolyporphin A. Unusual NMR spectroscopic shifts were observed for tolyporphin J (1) in CDCl3.

Original languageEnglish (US)
Pages (from-to)1133-1136
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number9
DOIs
StatePublished - Sep 1 1998

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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