Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa

Michèle R. Prinsep, Gregory M L Patterson, Linda K. Larsen, Charles Smith

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Two new porphinoids, tolyporphins J (1) and K (2), have been isolated from the terrestrial cyanobacterium, Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The activities of tolyporphins J and K in cell sensitization and drug accumulation assays for multidrug resistance (MDR) reversal were compared with those of tolyporphin A. Unusual NMR spectroscopic shifts were observed for tolyporphin J (1) in CDCl3.

Original languageEnglish (US)
Pages (from-to)1133-1136
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number9
DOIs
StatePublished - Sep 1998

Fingerprint

Tolypothrix
multiple drug resistance
Cyanobacteria
Multiple Drug Resistance
Metabolites
spectral analysis
Nuclear magnetic resonance
metabolites
drugs
assays
Pharmaceutical Preparations
Spectrum analysis
Assays
cells
tolyporphin J
tolyporphin

All Science Journal Classification (ASJC) codes

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Prinsep, Michèle R. ; Patterson, Gregory M L ; Larsen, Linda K. ; Smith, Charles. / Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa. In: Journal of Natural Products. 1998 ; Vol. 61, No. 9. pp. 1133-1136.
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Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa. / Prinsep, Michèle R.; Patterson, Gregory M L; Larsen, Linda K.; Smith, Charles.

In: Journal of Natural Products, Vol. 61, No. 9, 09.1998, p. 1133-1136.

Research output: Contribution to journalArticle

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