Topology, dynamics, and control in cortical blood flow elucidated with optical techniques

Philbert S. Tsai, Pablo Blinder, Patrick James Drew, Jonathan Driscoll, Diana Jeong, John P. Kaufhold, Andy Shih, Ilya Valmianski, David Kleinfeld

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Blood is a limited resource that supplies neurons and glia with nutriments. How is blood distributed both in a fail-safe way and in response to changing metabolic loads? We examine this issue in rodent cortex. First, in terms of topology, all-optical histology is used to reconstruct the vasculature network. Second, in terms of dynamics, the flux of blood cells in individual vessels is measured in response to neuronal activation and/or the perturbation of flow of a targeted vessel via plasma-mediated ablation. Lastly, in terms of control, optical indicators of neurovascular signaling molecules that alter vessel diameter are measured.

Original languageEnglish (US)
Title of host publicationBiosensing II
Volume7397
DOIs
StatePublished - Dec 1 2009
EventBiosensing II - San Diego, CA, United States
Duration: Aug 4 2009Aug 6 2009

Other

OtherBiosensing II
CountryUnited States
CitySan Diego, CA
Period8/4/098/6/09

All Science Journal Classification (ASJC) codes

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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  • Cite this

    Tsai, P. S., Blinder, P., Drew, P. J., Driscoll, J., Jeong, D., Kaufhold, J. P., Shih, A., Valmianski, I., & Kleinfeld, D. (2009). Topology, dynamics, and control in cortical blood flow elucidated with optical techniques. In Biosensing II (Vol. 7397). [739718] https://doi.org/10.1117/12.829588