Total synthesis of Adda, the unique C20 amino acid of cyanobacterial hepatotoxins

Michio Namikoshi, Kenneth L. Rinehart, Andrew M. Dahlem, Val R. Beasley, Wayne W. Carmichael

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

Synthetic (2S,3R)-3-Amino-4-hydroxy-2-methylbutanoic acid, γ-lactone, and (4S,5S)-2,4-dimethyl-5- methoxy-6-phenyl-2-hexen-1-ol were oxidized and linked to give (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8- trimethyl-10-phenyl-4,6-decadienoic acid (Adda).

Original languageEnglish (US)
Pages (from-to)4349-4352
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number33
DOIs
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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