Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai

Matthew L. Meketa, Steven M. Weinreb

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.

Original languageEnglish (US)
Pages (from-to)1443-1446
Number of pages4
JournalOrganic Letters
Volume8
Issue number7
DOIs
StatePublished - Mar 30 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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