Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai

Matthew L. Meketa; Steven M. Weinreb

doi:10.1021/ol0602304

Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai

Matthew L. Meketa, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

81 Citations (SciVal)

Abstract

A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.

Original language	English (US)
Pages (from-to)	1443-1446
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	7
DOIs	https://doi.org/10.1021/ol0602304
State	Published - Mar 30 2006

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol0602304

Cite this

@article{26cf0bccc5f845d88d062af51818043e,

title = "Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai",

abstract = "A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.",

author = "Meketa, {Matthew L.} and Weinreb, {Steven M.}",

year = "2006",

month = mar,

day = "30",

doi = "10.1021/ol0602304",

language = "English (US)",

volume = "8",

pages = "1443--1446",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai

AU - Meketa, Matthew L.

AU - Weinreb, Steven M.

PY - 2006/3/30

Y1 - 2006/3/30

N2 - A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.

AB - A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.

UR - http://www.scopus.com/inward/record.url?scp=33645919009&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645919009&partnerID=8YFLogxK

U2 - 10.1021/ol0602304

DO - 10.1021/ol0602304

M3 - Article

C2 - 16562912

AN - SCOPUS:33645919009

SN - 1523-7060

VL - 8

SP - 1443

EP - 1446

JO - Organic Letters

JF - Organic Letters

IS - 7

ER -

Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this