Total synthesis of Cinncassin A1

Ahmed Y. Nuriye, Cristina V. Craescu

Research output: Contribution to journalArticlepeer-review

Abstract

In this communication, we report the first total synthesis of the phenolic natural product Cinncassin A1, which was recently isolated from the twigs of the cinnamon plant (Cinnamomum cassia). The novel and concise synthesis strategy involves a highly diastereoselective titanium enolate homocoupling and a permanganate-mediated oxidative lactonization reaction as key steps. The structure of the compound was verified by single-crystal X-ray crystallography.

Original languageEnglish (US)
Pages (from-to)2640-2648
Number of pages9
JournalJournal of Heterocyclic Chemistry
Volume57
Issue number6
DOIs
StatePublished - Jun 1 2020

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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