A concise, diastereoselective total synthesis of (±)-cortistatin J has been completed in 20 steps from furan. Key steps include an intramolecular [4 + 3] cyclization of a disubstituted furan with a (Z)-2-(trialkylsilyloxy)-2- enal to construct the tetracyclic core and a (Z)-vinylsilane/iminium ion cyclization to form the A ring.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of the American Chemical Society|
|State||Published - Aug 17 2011|
All Science Journal Classification (ASJC) codes
- Colloid and Surface Chemistry