Total synthesis of (±)-dragmacidin e

Ken S. Feldman, Paiboon Ngernmeesri

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The bis indole sponge alkaloid dragmacidin E was synthesized in racemic form over 25 steps starting from 7-benzhydroxyindole. Key steps include (a) a Witkop cyclization to facilitate construction of the indole-spanning seven-membered ring and (b) a cyclodehydrative pyrazinone synthesis that unites the two indole-containing sectors.

Original languageEnglish (US)
Pages (from-to)5704-5707
Number of pages4
JournalOrganic Letters
Volume13
Issue number20
DOIs
StatePublished - Oct 21 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Feldman, K. S., & Ngernmeesri, P. (2011). Total synthesis of (±)-dragmacidin e. Organic Letters, 13(20), 5704-5707. https://doi.org/10.1021/ol202535f