Total synthesis of (-)-nakadomarin A

Mark G. Nilson, Raymond L. Funk

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A concise diastereoselective total synthesis of (-)-nakadomarin A has been completed in 21 steps from d-pyroglutamic acid. Key steps include an enecarbamate Michael addition/furan-N-acyliminium ion cascade cyclization to provide the tetracyclic core and ring-closing alkyne and alkene metatheses to construct the fifteen- and eight-membered azacycles, respectively.

Original languageEnglish (US)
Pages (from-to)4912-4915
Number of pages4
JournalOrganic Letters
Volume12
Issue number21
DOIs
StatePublished - Nov 5 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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