Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

Nolan R. Mente, Andrew J. Wiemer, Jeffrey D. Neighbors, John A. Beutler, Raymond J. Hohl, David F. Wiemer

Research output: Contribution to journalArticle

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Total synthesis of the (R,R,R)- and (S,S,S)-enantiomers of the natural product schweinfurthin F has been completed. Comparisons of spectral data and optical rotations with those reported for the natural product, as well as a variety of bioassay data, allow assignment of the natural material as the (R,R,R)-isomer.

Original languageEnglish (US)
Pages (from-to)911-915
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number4
StatePublished - Feb 15 2007


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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