Toward precision smoking cessation treatment I: Moderator results from a factorial experiment

Megan E. Piper, Tanya R. Schlam, Jessica W. Cook, Stevens S. Smith, Daniel M. Bolt, Wei Yin Loh, Robin Mermelstein, Linda M. Collins, Michael C. Fiore, Timothy B. Baker

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background The development of tobacco use treatments that are effective for all smokers is critical to improving clinical and public health. The Multiphase Optimization Strategy (MOST) uses highly efficient factorial experiments to evaluate multiple intervention components for possible inclusion in an optimized tobacco use treatment. Factorial experiments permit analyses of the influence of patient characteristics on main and interaction effects of multiple, relatively discrete, intervention components. This study examined whether person-factor and smoking characteristics moderated the main or interactive effects of intervention components on 26-week self-reported abstinence rates. Methods This fractional factorial experiment evaluated six smoking cessation intervention components among primary care patients (N = 637): Prequit Nicotine Patch vs. None, Prequit Nicotine Gum vs. None, Preparation Counseling vs. None, Intensive Cessation In-Person Counseling vs. Minimal, Intensive Cessation Telephone Counseling vs. Minimal, and 16 vs. 8 Weeks of Combination Nicotine Replacement Therapy (NRT; nicotine patch + nicotine gum). Results Both psychiatric history and smoking heaviness moderated intervention component effects. In comparison with participants with no self-reported history of a psychiatric disorder, those with a positive history showed better response to 16- vs. 8-weeks of combination NRT, but a poorer response to counseling interventions. Also, in contrast to light smokers, heavier smokers showed a poorer response to counseling interventions. Conclusions Heavy smokers and those with psychiatric histories demonstrated a differential response to intervention components. This research illustrates the use of factorial designs to examine the interactions between person characteristics and relatively discrete intervention components. Future research is needed to replicate these findings.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalDrug and alcohol dependence
Volume171
DOIs
StatePublished - Feb 1 2017

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Withholding Treatment
Moderators
Smoking Cessation
Nicotine
Tobacco Use Cessation Products
Counseling
Tobacco
Psychiatry
Tobacco Use
Experiments
Public health
Telephone
Smoking
Primary Health Care
Therapeutics
Public Health
History
Research

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Piper, M. E., Schlam, T. R., Cook, J. W., Smith, S. S., Bolt, D. M., Loh, W. Y., ... Baker, T. B. (2017). Toward precision smoking cessation treatment I: Moderator results from a factorial experiment. Drug and alcohol dependence, 171, 59-65. https://doi.org/10.1016/j.drugalcdep.2016.11.025
Piper, Megan E. ; Schlam, Tanya R. ; Cook, Jessica W. ; Smith, Stevens S. ; Bolt, Daniel M. ; Loh, Wei Yin ; Mermelstein, Robin ; Collins, Linda M. ; Fiore, Michael C. ; Baker, Timothy B. / Toward precision smoking cessation treatment I : Moderator results from a factorial experiment. In: Drug and alcohol dependence. 2017 ; Vol. 171. pp. 59-65.
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Piper, ME, Schlam, TR, Cook, JW, Smith, SS, Bolt, DM, Loh, WY, Mermelstein, R, Collins, LM, Fiore, MC & Baker, TB 2017, 'Toward precision smoking cessation treatment I: Moderator results from a factorial experiment', Drug and alcohol dependence, vol. 171, pp. 59-65. https://doi.org/10.1016/j.drugalcdep.2016.11.025

Toward precision smoking cessation treatment I : Moderator results from a factorial experiment. / Piper, Megan E.; Schlam, Tanya R.; Cook, Jessica W.; Smith, Stevens S.; Bolt, Daniel M.; Loh, Wei Yin; Mermelstein, Robin; Collins, Linda M.; Fiore, Michael C.; Baker, Timothy B.

In: Drug and alcohol dependence, Vol. 171, 01.02.2017, p. 59-65.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Toward precision smoking cessation treatment I

T2 - Moderator results from a factorial experiment

AU - Piper, Megan E.

AU - Schlam, Tanya R.

AU - Cook, Jessica W.

AU - Smith, Stevens S.

AU - Bolt, Daniel M.

AU - Loh, Wei Yin

AU - Mermelstein, Robin

AU - Collins, Linda M.

AU - Fiore, Michael C.

AU - Baker, Timothy B.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Background The development of tobacco use treatments that are effective for all smokers is critical to improving clinical and public health. The Multiphase Optimization Strategy (MOST) uses highly efficient factorial experiments to evaluate multiple intervention components for possible inclusion in an optimized tobacco use treatment. Factorial experiments permit analyses of the influence of patient characteristics on main and interaction effects of multiple, relatively discrete, intervention components. This study examined whether person-factor and smoking characteristics moderated the main or interactive effects of intervention components on 26-week self-reported abstinence rates. Methods This fractional factorial experiment evaluated six smoking cessation intervention components among primary care patients (N = 637): Prequit Nicotine Patch vs. None, Prequit Nicotine Gum vs. None, Preparation Counseling vs. None, Intensive Cessation In-Person Counseling vs. Minimal, Intensive Cessation Telephone Counseling vs. Minimal, and 16 vs. 8 Weeks of Combination Nicotine Replacement Therapy (NRT; nicotine patch + nicotine gum). Results Both psychiatric history and smoking heaviness moderated intervention component effects. In comparison with participants with no self-reported history of a psychiatric disorder, those with a positive history showed better response to 16- vs. 8-weeks of combination NRT, but a poorer response to counseling interventions. Also, in contrast to light smokers, heavier smokers showed a poorer response to counseling interventions. Conclusions Heavy smokers and those with psychiatric histories demonstrated a differential response to intervention components. This research illustrates the use of factorial designs to examine the interactions between person characteristics and relatively discrete intervention components. Future research is needed to replicate these findings.

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