Towards bioinspired parylene-C coatings of implant surfaces

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

The external surfaces of an implanted prosthesis must be biocompatible. As the properties of a biological surface vary, often gradually but also abruptly, the implant surface should be endowed with a gradient of surface roughness and wettability for good integration with proteins and cells. We have made free-standing, flexible, fibrous, nano/micro-textured thin films of parylene-C with thickness-controlled surface morphology and hydrophobicity; furthermore, varying degrees of hydrophilicity are displayed after oxygen-plasma treatment. The bioinspired thin films are mechanically robust and have been shown to support both protein binding and cellular attachment as well as growth. By conformally covering an implant surface with patches of these thin films of varying thickness and oxygen-plasma-treatment duration, gradients of protein/cell attachment can be tailored and thus tissue integration can be managed on different parts of the implant surface.

Original languageEnglish (US)
Title of host publicationBioinspiration, Biomimetics, and Bioreplication 2012
Volume8339
DOIs
StatePublished - May 14 2012
EventBioinspiration, Biomimetics, and Bioreplication 2012 - San Diego, CA, United States
Duration: Mar 12 2012Mar 15 2012

Other

OtherBioinspiration, Biomimetics, and Bioreplication 2012
CountryUnited States
CitySan Diego, CA
Period3/12/123/15/12

Fingerprint

Implant
Coating
coatings
Coatings
Thin Films
Protein
Thin films
oxygen plasma
Oxygen
proteins
Plasma
attachment
Gradient
Proteins
Plasmas
Wettability
thin films
Hydrophobicity
Surface Morphology
Cell

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Wei, L., & Lakhtakia, A. (2012). Towards bioinspired parylene-C coatings of implant surfaces. In Bioinspiration, Biomimetics, and Bioreplication 2012 (Vol. 8339). [83390R] https://doi.org/10.1117/12.914939
Wei, Lai ; Lakhtakia, Akhlesh. / Towards bioinspired parylene-C coatings of implant surfaces. Bioinspiration, Biomimetics, and Bioreplication 2012. Vol. 8339 2012.
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Wei, L & Lakhtakia, A 2012, Towards bioinspired parylene-C coatings of implant surfaces. in Bioinspiration, Biomimetics, and Bioreplication 2012. vol. 8339, 83390R, Bioinspiration, Biomimetics, and Bioreplication 2012, San Diego, CA, United States, 3/12/12. https://doi.org/10.1117/12.914939

Towards bioinspired parylene-C coatings of implant surfaces. / Wei, Lai; Lakhtakia, Akhlesh.

Bioinspiration, Biomimetics, and Bioreplication 2012. Vol. 8339 2012. 83390R.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - The external surfaces of an implanted prosthesis must be biocompatible. As the properties of a biological surface vary, often gradually but also abruptly, the implant surface should be endowed with a gradient of surface roughness and wettability for good integration with proteins and cells. We have made free-standing, flexible, fibrous, nano/micro-textured thin films of parylene-C with thickness-controlled surface morphology and hydrophobicity; furthermore, varying degrees of hydrophilicity are displayed after oxygen-plasma treatment. The bioinspired thin films are mechanically robust and have been shown to support both protein binding and cellular attachment as well as growth. By conformally covering an implant surface with patches of these thin films of varying thickness and oxygen-plasma-treatment duration, gradients of protein/cell attachment can be tailored and thus tissue integration can be managed on different parts of the implant surface.

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Wei L, Lakhtakia A. Towards bioinspired parylene-C coatings of implant surfaces. In Bioinspiration, Biomimetics, and Bioreplication 2012. Vol. 8339. 2012. 83390R https://doi.org/10.1117/12.914939