Towards malaria elimination in Savannakhet, Lao PDR: Mathematical modelling driven strategy design

Sai Thein Than Tun, Lorenz Von Seidlein, Tiengkham Pongvongsa, Mayfong Mayxay, Sompob Saralamba, Shwe Sin Kyaw, Phetsavanh Chanthavilay, Olivier Celhay, Tran Dang Nguyen, Thu Nguyen Anh Tran, Daniel M. Parker, Maciej F. Boni, Arjen M. Dondorp, Lisa J. White

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The number of Plasmodium falciparum malaria cases around the world has decreased substantially over the last 15 years, but with the spread of resistance against anti-malarial drugs and insecticides, this decline may not continue. There is an urgent need to consider alternative, accelerated strategies to eliminate malaria in countries like Lao PDR, where there are a few remaining endemic areas. A deterministic compartmental modelling tool was used to develop an integrated strategy for P. falciparum elimination in the Savannakhet province of Lao PDR. The model was designed to include key aspects of malaria transmission and integrated control measures, along with a user-friendly interface. Results: Universal coverage was the foundation of the integrated strategy, which took the form of the deployment of community health workers who provided universal access to early diagnosis, treatment and long-lasting insecticidal nets. Acceleration was included as the deployment of three monthly rounds of mass drug administration targeted towards high prevalence villages, with the addition of three monthly doses of the RTS,S vaccine delivered en masse to the same high prevalence sub-population. A booster dose of vaccine was added 1 year later. The surveillance-as-intervention component of the package involved the screening and treatment of individuals entering the simulated population. Conclusions: In this modelling approach, the sequential introduction of a series of five available interventions in an integrated strategy was predicted to be sufficient to stop malaria transmission within a 3-year period. These interventions comprised universal access to early diagnosis and adequate treatment, improved access to long-lasting insecticidal nets, three monthly rounds of mass drug administration together with RTS,S vaccination followed by a booster dose of vaccine, and screening and treatment of imported cases.

Original languageEnglish (US)
Article number483
JournalMalaria journal
Volume16
Issue number1
DOIs
StatePublished - Nov 28 2017

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Laos
Malaria
Vaccines
Early Diagnosis
Universal Coverage
Pharmaceutical Preparations
Falciparum Malaria
Antimalarials
Therapeutics
Plasmodium falciparum
Insecticides
Population
Vaccination

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

Cite this

Tun, S. T. T., Von Seidlein, L., Pongvongsa, T., Mayxay, M., Saralamba, S., Kyaw, S. S., ... White, L. J. (2017). Towards malaria elimination in Savannakhet, Lao PDR: Mathematical modelling driven strategy design. Malaria journal, 16(1), [483]. https://doi.org/10.1186/s12936-017-2130-3
Tun, Sai Thein Than ; Von Seidlein, Lorenz ; Pongvongsa, Tiengkham ; Mayxay, Mayfong ; Saralamba, Sompob ; Kyaw, Shwe Sin ; Chanthavilay, Phetsavanh ; Celhay, Olivier ; Nguyen, Tran Dang ; Tran, Thu Nguyen Anh ; Parker, Daniel M. ; Boni, Maciej F. ; Dondorp, Arjen M. ; White, Lisa J. / Towards malaria elimination in Savannakhet, Lao PDR : Mathematical modelling driven strategy design. In: Malaria journal. 2017 ; Vol. 16, No. 1.
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abstract = "Background: The number of Plasmodium falciparum malaria cases around the world has decreased substantially over the last 15 years, but with the spread of resistance against anti-malarial drugs and insecticides, this decline may not continue. There is an urgent need to consider alternative, accelerated strategies to eliminate malaria in countries like Lao PDR, where there are a few remaining endemic areas. A deterministic compartmental modelling tool was used to develop an integrated strategy for P. falciparum elimination in the Savannakhet province of Lao PDR. The model was designed to include key aspects of malaria transmission and integrated control measures, along with a user-friendly interface. Results: Universal coverage was the foundation of the integrated strategy, which took the form of the deployment of community health workers who provided universal access to early diagnosis, treatment and long-lasting insecticidal nets. Acceleration was included as the deployment of three monthly rounds of mass drug administration targeted towards high prevalence villages, with the addition of three monthly doses of the RTS,S vaccine delivered en masse to the same high prevalence sub-population. A booster dose of vaccine was added 1 year later. The surveillance-as-intervention component of the package involved the screening and treatment of individuals entering the simulated population. Conclusions: In this modelling approach, the sequential introduction of a series of five available interventions in an integrated strategy was predicted to be sufficient to stop malaria transmission within a 3-year period. These interventions comprised universal access to early diagnosis and adequate treatment, improved access to long-lasting insecticidal nets, three monthly rounds of mass drug administration together with RTS,S vaccination followed by a booster dose of vaccine, and screening and treatment of imported cases.",
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Tun, STT, Von Seidlein, L, Pongvongsa, T, Mayxay, M, Saralamba, S, Kyaw, SS, Chanthavilay, P, Celhay, O, Nguyen, TD, Tran, TNA, Parker, DM, Boni, MF, Dondorp, AM & White, LJ 2017, 'Towards malaria elimination in Savannakhet, Lao PDR: Mathematical modelling driven strategy design', Malaria journal, vol. 16, no. 1, 483. https://doi.org/10.1186/s12936-017-2130-3

Towards malaria elimination in Savannakhet, Lao PDR : Mathematical modelling driven strategy design. / Tun, Sai Thein Than; Von Seidlein, Lorenz; Pongvongsa, Tiengkham; Mayxay, Mayfong; Saralamba, Sompob; Kyaw, Shwe Sin; Chanthavilay, Phetsavanh; Celhay, Olivier; Nguyen, Tran Dang; Tran, Thu Nguyen Anh; Parker, Daniel M.; Boni, Maciej F.; Dondorp, Arjen M.; White, Lisa J.

In: Malaria journal, Vol. 16, No. 1, 483, 28.11.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Towards malaria elimination in Savannakhet, Lao PDR

T2 - Mathematical modelling driven strategy design

AU - Tun, Sai Thein Than

AU - Von Seidlein, Lorenz

AU - Pongvongsa, Tiengkham

AU - Mayxay, Mayfong

AU - Saralamba, Sompob

AU - Kyaw, Shwe Sin

AU - Chanthavilay, Phetsavanh

AU - Celhay, Olivier

AU - Nguyen, Tran Dang

AU - Tran, Thu Nguyen Anh

AU - Parker, Daniel M.

AU - Boni, Maciej F.

AU - Dondorp, Arjen M.

AU - White, Lisa J.

PY - 2017/11/28

Y1 - 2017/11/28

N2 - Background: The number of Plasmodium falciparum malaria cases around the world has decreased substantially over the last 15 years, but with the spread of resistance against anti-malarial drugs and insecticides, this decline may not continue. There is an urgent need to consider alternative, accelerated strategies to eliminate malaria in countries like Lao PDR, where there are a few remaining endemic areas. A deterministic compartmental modelling tool was used to develop an integrated strategy for P. falciparum elimination in the Savannakhet province of Lao PDR. The model was designed to include key aspects of malaria transmission and integrated control measures, along with a user-friendly interface. Results: Universal coverage was the foundation of the integrated strategy, which took the form of the deployment of community health workers who provided universal access to early diagnosis, treatment and long-lasting insecticidal nets. Acceleration was included as the deployment of three monthly rounds of mass drug administration targeted towards high prevalence villages, with the addition of three monthly doses of the RTS,S vaccine delivered en masse to the same high prevalence sub-population. A booster dose of vaccine was added 1 year later. The surveillance-as-intervention component of the package involved the screening and treatment of individuals entering the simulated population. Conclusions: In this modelling approach, the sequential introduction of a series of five available interventions in an integrated strategy was predicted to be sufficient to stop malaria transmission within a 3-year period. These interventions comprised universal access to early diagnosis and adequate treatment, improved access to long-lasting insecticidal nets, three monthly rounds of mass drug administration together with RTS,S vaccination followed by a booster dose of vaccine, and screening and treatment of imported cases.

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Tun STT, Von Seidlein L, Pongvongsa T, Mayxay M, Saralamba S, Kyaw SS et al. Towards malaria elimination in Savannakhet, Lao PDR: Mathematical modelling driven strategy design. Malaria journal. 2017 Nov 28;16(1). 483. https://doi.org/10.1186/s12936-017-2130-3