Toxicity evaluation for safe use of nanomaterials: Recent achievements and technical challenges

Saber M. Hussain, Laura K. Braydich-Stolle, Amanda M. Schrand, Richard C. Murdock, Kyung O. Yu, Mauricio Terrones Maldonado, John J. Schlager

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Recent developments in the field of nanotechnology involving the synthesis of novel nanomaterials (NM) have attracted the attention of numerous scientists owing to the possibility of degradative perturbations in human health. This Review evaluates previous investigations related to NM toxicity studies using biological models and describes the limitations that often prevent toxicologists from identifying whether NM pose a real hazard to human health. One major limitation to assess toxicity is the characterization of the NM prior to and after exposure to living cells or animals. The most relevant physicochemical characteristics of NM are: size, surface chemistry, crystallinity, morphology, solubility, aggregation tendency, homogeneity of dispersions, and turbidity. All of these properties need to be assessed in order to determine their contribution to toxicity. Due to the lack of appropriate methods to determine the physicochemical nature of nanoparticles in biological systems, the exact nature of NM toxicity is not fully described or understood at this time. This Review emphasizes the need for state-of-the-art physicochemical characterization, the determination of appropriate exposure protocols and reliable methods for assessing NM internalization and their kinetics in living organisms. Once these issues are addressed, optimal experimental conditions could be established in order to identify if NM pose a threat to human health. Multidisciplinary research between materials scientists and life scientists should overcome these limitations in identifying the true hazards of NM.

Original languageEnglish (US)
Pages (from-to)1549-1559
Number of pages11
JournalAdvanced Materials
Volume21
Issue number16
DOIs
StatePublished - Apr 27 2009

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Nanostructured materials
Toxicity
Health
Hazards
Turbidity
Biological systems
Surface chemistry
Dispersions
Nanotechnology
Animals
Agglomeration
Solubility
Cells
Nanoparticles
Kinetics

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Hussain, S. M., Braydich-Stolle, L. K., Schrand, A. M., Murdock, R. C., Yu, K. O., Terrones Maldonado, M., & Schlager, J. J. (2009). Toxicity evaluation for safe use of nanomaterials: Recent achievements and technical challenges. Advanced Materials, 21(16), 1549-1559. https://doi.org/10.1002/adma.200801395
Hussain, Saber M. ; Braydich-Stolle, Laura K. ; Schrand, Amanda M. ; Murdock, Richard C. ; Yu, Kyung O. ; Terrones Maldonado, Mauricio ; Schlager, John J. / Toxicity evaluation for safe use of nanomaterials : Recent achievements and technical challenges. In: Advanced Materials. 2009 ; Vol. 21, No. 16. pp. 1549-1559.
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Hussain, SM, Braydich-Stolle, LK, Schrand, AM, Murdock, RC, Yu, KO, Terrones Maldonado, M & Schlager, JJ 2009, 'Toxicity evaluation for safe use of nanomaterials: Recent achievements and technical challenges', Advanced Materials, vol. 21, no. 16, pp. 1549-1559. https://doi.org/10.1002/adma.200801395

Toxicity evaluation for safe use of nanomaterials : Recent achievements and technical challenges. / Hussain, Saber M.; Braydich-Stolle, Laura K.; Schrand, Amanda M.; Murdock, Richard C.; Yu, Kyung O.; Terrones Maldonado, Mauricio; Schlager, John J.

In: Advanced Materials, Vol. 21, No. 16, 27.04.2009, p. 1549-1559.

Research output: Contribution to journalArticle

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