Toxin-antitoxin systems influence biofilm and persister cell formation and the general stress response

Xiaoxue Wang, Thomas K. Wood

Research output: Contribution to journalArticlepeer-review

271 Scopus citations

Abstract

In many genomes, toxin-antitoxin (TA) systems have been identified; however, their role in cell physiology has been unclear. Here we examine the evidence that TA systems are involved in biofilm formation and persister cell formation and that these systems may be important regulators of the switch from the planktonic to the biofilm lifestyle as a stress response by their control of secondary messenger 3',5'-cyclic diguanylic acid. Specifically, upon stress, the sequence-specific mRNA interferases MqsR and MazF mediate cell survival. In addition, we propose that TA systems are not redundant, as they may have developed to respond to specific stresses.

Original languageEnglish (US)
Pages (from-to)5577-5583
Number of pages7
JournalApplied and environmental microbiology
Volume77
Issue number16
DOIs
StatePublished - Aug 2011

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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