Traitor or warrior–Treg cells sneaking into the lesions of psoriatic arthritis

Yan Liu, Wael Jarjour, Nancy Olsen, Song Guo Zheng

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Regulatory T (Treg) cells have been recognized to maintain immune tolerance, which contributes to prevention of autoimmune diseases. However, recent evidence has demonstrated different characteristics of these cells between those that are in circulation compared to those in various local tissues. In addition, the ability of Treg cells to have plasticity in certain disease settings and in inflammatory lesions has been increasingly recognized. Herein we summarize updated knowledge of Treg biology and discuss the current understanding of tissue-resident Treg cells in psoriatic arthritis (PsA), attempting to provide new insights into precise role of Treg cells in the immune response and as a possible therapeutic intervention in patients with PsA.

Original languageEnglish (US)
Article number108425
JournalClinical Immunology
Volume215
DOIs
StatePublished - Jun 2020

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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