Transactivation of the human endogenous retrovirus K long terminal repeat by herpes simplex virus type 1 immediate early protein 0

Hyun Jin Kwun, Hae Jin Han, Woo Jung Lee, Hee Soo Kim, Kyung Lib Jang

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

We found that LTR-directed transcription of the human endogenous retrovirus K can be induced by HSV-1 infection. The effect was mediated by the action of a HSV-1 immediate early protein, ICP0 and required the AP-1 binding site present on the HERV-K LTR. In addition, ICP0 could up-regulate AP-1 activity, suggesting that ICP0 increases transcription of HERV-K through AP-1 site. This effect might be important to understand both HERV-K- and HSV-1-mediated pathogenesis because HERV-K LTR represents an important class of retrotranspositional mutagens and also could provide a new regulatory element for the linked DNA sequences.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalVirus Research
Volume86
Issue number1-2
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Virology
  • Infectious Diseases

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