Transcription factor AP-2 essential for cranial closure and craniofacial development

Hubert Schorle, Pascal Meier, Michael Buchert, Rudolf Jaenisch, Pamela J. Mitchell

Research output: Contribution to journalArticle

490 Scopus citations

Abstract

During closure of the neural tube in the mouse, transcription factor AP-2 is expressed in ectoderm and in neural-crest cells migrating from the cranial neural folds. Cranial neural crest cells provide patterning information for craniofacial morphogenesis, generate most of the skull bones, and, together with placodal ectoderm, form the cranial ganglia. To study the role of AP-2 during embryogenesis, we undertook a targeted mutagenesis of the AP-2 gene in the mouse. Here we report that AP-2(-/-) mice died perinatally with cranio-abdominoschisis and severe dismorphogenesis of the face, skull, sensory organs and cranial ganglia. Failure of cranial closure between 9 and 9.5 days postcoitum coincided with increased apoptosis in the midbrain, anterior hindbrain and proximal mesenchyme of the first branchial arch, but did not involve loss of expression of twist or Pax-3, two other regulatory genes known to be required for cranial closure.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalNature
Volume381
Issue number6579
DOIs
StatePublished - May 16 1996

All Science Journal Classification (ASJC) codes

  • General

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    Schorle, H., Meier, P., Buchert, M., Jaenisch, R., & Mitchell, P. J. (1996). Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature, 381(6579), 235-238. https://doi.org/10.1038/381235a0