In eukaryotes, the TATA box-binding protein (TBP) is responsible for nucleating assembly of the transcription initiation machinery. Here, we report that a TFIID complex containing TBP is essential for transcription even at a promoter that lacks a TATA box. Immunopurification of TFIID reveals that the active species in reconstituting TATA-less transcription is a multisubunit complex consisting of TBP and many TBP-associated factors (TAFs).
|Original language||English (US)|
|Number of pages||11|
|Journal||Genes and Development|
|State||Published - 1991|
All Science Journal Classification (ASJC) codes
- Developmental Biology