Transcriptional enhancers: Bridging the genome and phenome

Bing Ren, Feng Yue

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Abstract

Enhancers play a major role in animal development by modulating spatiotemporal expression of genes. They interact with sequence-specific transcriptional regulators in response to internal and external cues to bring about transcriptional changes, thus serving as the critical link between an organism's genome and its phenotypic traits. Deciphering the biology of enhancers is a key to understanding the genetic basis of common human diseases. Although a large number of candidate enhancers have been annotated through genome-wide analyses of chromatin accessibility, transcription factor binding, and histone modification in diverse cell types, efforts to characterize their biological roles in human diseases have only begun. Recent experiments have suggested a role for the three-dimensional chromatin architecture in regulation of gene expression by enhancers.

Original languageEnglish (US)
Title of host publication21st Century Genetics Genes at Work, 2015
EditorsTerri Grodzicker, Bruce Stillman, David Stewart
PublisherCold Spring Harbor Laboratory Press
Pages17-26
Number of pages10
ISBN (Print)9781621821472
DOIs
StatePublished - Jan 1 2016
Event21st Century Genetics Genes at Work, 2015 - Huntington, United States
Duration: May 26 2015May 31 2015

Publication series

NameCold Spring Harbor Symposia on Quantitative Biology
Volume80
ISSN (Print)0091-7451
ISSN (Electronic)1943-4456

Other

Other21st Century Genetics Genes at Work, 2015
CountryUnited States
CityHuntington
Period5/26/155/31/15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

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  • Cite this

    Ren, B., & Yue, F. (2016). Transcriptional enhancers: Bridging the genome and phenome. In T. Grodzicker, B. Stillman, & D. Stewart (Eds.), 21st Century Genetics Genes at Work, 2015 (pp. 17-26). (Cold Spring Harbor Symposia on Quantitative Biology; Vol. 80). Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/sqb.2015.80.027219