Transcriptional mechanisms regulating Ca2+ homeostasis

Michael F. Ritchie, Yandong Zhou, Jonathan Soboloff

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Ca2+ is a dynamic cellular secondary messenger which mediates a vast array of cellular responses. Control over these processes is achieved via an extensive combination of pumps and channels which regulate the concentration of Ca2+ within not only the cytosol but also all intracellular compartments. Precisely how these pumps and channels are regulated is only partially understood, however, recent investigations have identified members of the Early Growth Response (EGR) family of zinc finger transcription factors as critical players in this process. The roles of several other transcription factors in control of Ca2+ homeostasis have also been demonstrated, including Wilms Tumor Suppressor 1 (WT1), Nuclear Factor of Activated T cells (NFAT) and c-myc. In this review, we will discuss not only how these transcription factors regulate the expression of the major proteins involved in control of Ca2+ homeostasis, but also how this transcriptional remodeling of Ca2+ homeostasis affects Ca2+ dynamics and cellular responses.

Original languageEnglish (US)
Pages (from-to)314-321
Number of pages8
JournalCell Calcium
Volume49
Issue number5
DOIs
StatePublished - May 2011

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

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