Transcriptional regulation of genes by ikaros tumor suppressor in acute lymphoblastic leukemia

Pavan Kumar Dhanyamraju, Soumya Iyer, Gayle Smink, Yevgeniya Bamme, Preeti Bhadauria, Jonathon L. Payne, Elanora Dovat, Morgann Klink, Yali Ding

Research output: Contribution to journalReview article

Abstract

Regulation of oncogenic gene expression by transcription factors that function as tumor suppressors is one of the major mechanisms that regulate leukemogenesis. Understanding this complex process is essential for explaining the pathogenesis of leukemia as well as developing targeted therapies. Here, we provide an overview of the role of Ikaros tumor suppressor and its role in regulation of gene transcription in acute leukemia. Ikaros (IKZF1) is a DNA-binding protein that functions as a master regulator of hematopoiesis and the immune system, as well as a tumor suppressor in acute lymphoblastic leukemia (ALL). Genetic alteration or functional inactivation of Ikaros results in the development of high-risk leukemia. Ikaros binds to the specific consensus binding motif at upstream regulatory elements of its target genes, recruits chromatin-remodeling complexes and activates or represses transcription via chromatin remodeling. Over the last twenty years, a large number of Ikaros target genes have been identified, and the role of Ikaros in the regulation of their expression provided insight into the mechanisms of Ikaros tumor suppressor function in leukemia. Here we summarize the role of Ikaros in the regulation of the expression of the genes whose function is critical for cellular proliferation, development, and progression of acute lymphoblastic leukemia.

Original languageEnglish (US)
Article number1377
JournalInternational journal of molecular sciences
Volume21
Issue number4
DOIs
StatePublished - Feb 2 2020

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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  • Cite this

    Dhanyamraju, P. K., Iyer, S., Smink, G., Bamme, Y., Bhadauria, P., Payne, J. L., Dovat, E., Klink, M., & Ding, Y. (2020). Transcriptional regulation of genes by ikaros tumor suppressor in acute lymphoblastic leukemia. International journal of molecular sciences, 21(4), [1377]. https://doi.org/10.3390/ijms21041377