TY - JOUR
T1 - Transcriptional regulation of repressor synthesis in mycobacteriophage L5
AU - Nesbit, Chadd E.
AU - Levin, Margaret E.
AU - Donnelly‐Wu, Mary K.
AU - Hatfull, Graham F.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1995/9
Y1 - 1995/9
N2 - Mycobacteriophage L5 is a temperate phage of the mycobacteria that forms stable lysogens in Mycobacterium smegmatis. Lysogeny is maintained by the putative repressor, the gene 71 product, which also mediates immunity to superinfection. We show here that there are three promoters located upstream of gene 71 which are active in an L5 lysogen but which do not require any phage‐encoded proteins. In early lytic growth, gene 71 is also transcribed from a promoter, Pleft, located at the right end of the genome and which appears to be a target of gp71 regulation. A model is given for the regulation of L5 life cycles.
AB - Mycobacteriophage L5 is a temperate phage of the mycobacteria that forms stable lysogens in Mycobacterium smegmatis. Lysogeny is maintained by the putative repressor, the gene 71 product, which also mediates immunity to superinfection. We show here that there are three promoters located upstream of gene 71 which are active in an L5 lysogen but which do not require any phage‐encoded proteins. In early lytic growth, gene 71 is also transcribed from a promoter, Pleft, located at the right end of the genome and which appears to be a target of gp71 regulation. A model is given for the regulation of L5 life cycles.
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U2 - 10.1111/j.1365-2958.1995.mmi_17061045.x
DO - 10.1111/j.1365-2958.1995.mmi_17061045.x
M3 - Article
C2 - 8594325
AN - SCOPUS:0028800051
SN - 0950-382X
VL - 17
SP - 1045
EP - 1056
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 6
ER -