Transcriptional regulation of repressor synthesis in mycobacteriophage L5

Chadd E. Nesbit, Margaret E. Levin, Mary K. Donnelly‐Wu, Graham F. Hatfull

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Mycobacteriophage L5 is a temperate phage of the mycobacteria that forms stable lysogens in Mycobacterium smegmatis. Lysogeny is maintained by the putative repressor, the gene 71 product, which also mediates immunity to superinfection. We show here that there are three promoters located upstream of gene 71 which are active in an L5 lysogen but which do not require any phage‐encoded proteins. In early lytic growth, gene 71 is also transcribed from a promoter, Pleft, located at the right end of the genome and which appears to be a target of gp71 regulation. A model is given for the regulation of L5 life cycles.

Original languageEnglish (US)
Pages (from-to)1045-1056
Number of pages12
JournalMolecular Microbiology
Issue number6
StatePublished - Sep 1995

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology


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