Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2

Hyun Jin Kwun, Jae Hwa Lee, Do Sik Min, Kyung Lib Jang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Phospholipase D (PLD) is known to stimulate cell cycle progression and to transform murine fibroblast cells into tumorigenic forms, although the precise mechanisms are not elucidated. In this report, we demonstrated that both PLD1 and PLD2 repressed expression of cyclin-dependent kinase inhibitor p21 gene in an additive manner. The phospholipase activity of PLDs was important for the effect. PLD1 repressed the p21 promoter by decreasing the level of p53, whereas PLD2 via a p53-independent pathway through modulating Sp1 activity. Taken together, we suggest that PLD isozymes stimulate cell growth by repressing expression of p21 gene, which may ultimately lead to carcinogenesis.

Original languageEnglish (US)
Pages (from-to)38-44
Number of pages7
JournalFEBS Letters
Volume544
Issue number1-3
DOIs
StatePublished - Jun 5 2003

Fingerprint

Cyclin-Dependent Kinase Inhibitor p21
Phospholipase D
Genes
Cells
Phospholipases
Cell growth
Fibroblasts
Isoenzymes
Cell Cycle
Carcinogenesis
Gene Expression
Growth
phospholipase D1
phospholipase D2
1-dodecylpyridoxal

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Kwun, Hyun Jin ; Lee, Jae Hwa ; Min, Do Sik ; Jang, Kyung Lib. / Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2. In: FEBS Letters. 2003 ; Vol. 544, No. 1-3. pp. 38-44.
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Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2. / Kwun, Hyun Jin; Lee, Jae Hwa; Min, Do Sik; Jang, Kyung Lib.

In: FEBS Letters, Vol. 544, No. 1-3, 05.06.2003, p. 38-44.

Research output: Contribution to journalArticle

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AB - Phospholipase D (PLD) is known to stimulate cell cycle progression and to transform murine fibroblast cells into tumorigenic forms, although the precise mechanisms are not elucidated. In this report, we demonstrated that both PLD1 and PLD2 repressed expression of cyclin-dependent kinase inhibitor p21 gene in an additive manner. The phospholipase activity of PLDs was important for the effect. PLD1 repressed the p21 promoter by decreasing the level of p53, whereas PLD2 via a p53-independent pathway through modulating Sp1 activity. Taken together, we suggest that PLD isozymes stimulate cell growth by repressing expression of p21 gene, which may ultimately lead to carcinogenesis.

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