Transcriptional response of avian cells to infection with Newcastle disease virus

Shirin Munir, Jagdev M. Sharma, Vivek Kapur

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Newcastle disease virus (NDV) causes widespread disease in poultry and wild-birds throughout the world. cDNA microarray analysis was used to examine the effect of NDV infection on host cell transcription. The results show that NDV infection causes an apparent suppression of the interferon response genes during the early stages of infection. In addition, the results reveal transcriptional silencing of cytoskeletal proteins such as the α, β, and γ types of actin, and a downregulation of the thioredoxin gene, a likely mediator of apoptosis with possible implications in NDV pathogenesis. Comparative analyses show that a majority of genes that were transcriptionally regulated during infection with another common respiratory pathogen of poultry, the avian pneumovirus, remained unaltered during NDV infection, suggesting that even phylogenetically related viruses elicit unique or "signature" patterns of host transcriptional profiles during infection of host cells.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalVirus Research
Volume107
Issue number1
DOIs
StatePublished - Jan 1 2005

Fingerprint

Newcastle disease virus
Virus Diseases
Infection
Poultry Diseases
Metapneumovirus
Genes
Thioredoxins
Cytoskeletal Proteins
Microarray Analysis
Poultry
Oligonucleotide Array Sequence Analysis
Interferons
Birds
Actins
Down-Regulation
Apoptosis
Viruses

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

Munir, Shirin ; Sharma, Jagdev M. ; Kapur, Vivek. / Transcriptional response of avian cells to infection with Newcastle disease virus. In: Virus Research. 2005 ; Vol. 107, No. 1. pp. 103-108.
@article{b8634322da6c4a5fb048fd8332fcf876,
title = "Transcriptional response of avian cells to infection with Newcastle disease virus",
abstract = "Newcastle disease virus (NDV) causes widespread disease in poultry and wild-birds throughout the world. cDNA microarray analysis was used to examine the effect of NDV infection on host cell transcription. The results show that NDV infection causes an apparent suppression of the interferon response genes during the early stages of infection. In addition, the results reveal transcriptional silencing of cytoskeletal proteins such as the α, β, and γ types of actin, and a downregulation of the thioredoxin gene, a likely mediator of apoptosis with possible implications in NDV pathogenesis. Comparative analyses show that a majority of genes that were transcriptionally regulated during infection with another common respiratory pathogen of poultry, the avian pneumovirus, remained unaltered during NDV infection, suggesting that even phylogenetically related viruses elicit unique or {"}signature{"} patterns of host transcriptional profiles during infection of host cells.",
author = "Shirin Munir and Sharma, {Jagdev M.} and Vivek Kapur",
year = "2005",
month = "1",
day = "1",
doi = "10.1016/j.virusres.2004.07.001",
language = "English (US)",
volume = "107",
pages = "103--108",
journal = "Virus Research",
issn = "0168-1702",
publisher = "Elsevier",
number = "1",

}

Transcriptional response of avian cells to infection with Newcastle disease virus. / Munir, Shirin; Sharma, Jagdev M.; Kapur, Vivek.

In: Virus Research, Vol. 107, No. 1, 01.01.2005, p. 103-108.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Transcriptional response of avian cells to infection with Newcastle disease virus

AU - Munir, Shirin

AU - Sharma, Jagdev M.

AU - Kapur, Vivek

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Newcastle disease virus (NDV) causes widespread disease in poultry and wild-birds throughout the world. cDNA microarray analysis was used to examine the effect of NDV infection on host cell transcription. The results show that NDV infection causes an apparent suppression of the interferon response genes during the early stages of infection. In addition, the results reveal transcriptional silencing of cytoskeletal proteins such as the α, β, and γ types of actin, and a downregulation of the thioredoxin gene, a likely mediator of apoptosis with possible implications in NDV pathogenesis. Comparative analyses show that a majority of genes that were transcriptionally regulated during infection with another common respiratory pathogen of poultry, the avian pneumovirus, remained unaltered during NDV infection, suggesting that even phylogenetically related viruses elicit unique or "signature" patterns of host transcriptional profiles during infection of host cells.

AB - Newcastle disease virus (NDV) causes widespread disease in poultry and wild-birds throughout the world. cDNA microarray analysis was used to examine the effect of NDV infection on host cell transcription. The results show that NDV infection causes an apparent suppression of the interferon response genes during the early stages of infection. In addition, the results reveal transcriptional silencing of cytoskeletal proteins such as the α, β, and γ types of actin, and a downregulation of the thioredoxin gene, a likely mediator of apoptosis with possible implications in NDV pathogenesis. Comparative analyses show that a majority of genes that were transcriptionally regulated during infection with another common respiratory pathogen of poultry, the avian pneumovirus, remained unaltered during NDV infection, suggesting that even phylogenetically related viruses elicit unique or "signature" patterns of host transcriptional profiles during infection of host cells.

UR - http://www.scopus.com/inward/record.url?scp=9644287961&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9644287961&partnerID=8YFLogxK

U2 - 10.1016/j.virusres.2004.07.001

DO - 10.1016/j.virusres.2004.07.001

M3 - Article

C2 - 15567039

AN - SCOPUS:9644287961

VL - 107

SP - 103

EP - 108

JO - Virus Research

JF - Virus Research

SN - 0168-1702

IS - 1

ER -