Transcriptomic comparison of the retina in two mouse models of diabetes

Willard M. Freeman, Georgina V. Bixler, Robert M. Brucklacher, Erin Walsh, Scot R. Kimball, Leonard S. Jefferson, Sarah K. Bronson

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Mouse models of type I diabetes offer the potential to combine genetic approaches with other pharmacological or physiological manipulations to investigate the pathophysiology and treatment of diabetic retinopathy. Type I diabetes is induced in mice through chemical toxins or can arise spontaneously from genetic mutations. Both models are associated with retinal vascular and neuronal changes. Retinal transcriptomic responses in C57BL/6J mice treated with streptozotocin and Ins2Akita/+ were compared after 3 months of hyperglycemia. Specific gene expression changes suggest a neurovascular inflammatory response in diabetic retinopathy. Genes common to the two models may represent theresponse of the retina to hyperglycemia, while changes unique to each model may represent time-dependent disease progression differences in the various models. Further investigation of the commonalities and differences between mouse models of type I diabetes may define cause and effect events in early diabetic retinopathy disease progression.

Original languageEnglish (US)
Pages (from-to)202-213
Number of pages12
JournalJournal of Ocular Biology, Diseases, and Informatics
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2009

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Genetics

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