Transfer entropy between cortical and basal ganglia electrophysiology

Timothy P. Gilmour, Constantino Manuel Lagoa, William Kenneth Jenkins, Anand N. Rao, Matthew A. Berk, Kala Venkiteswaran, Thyagarajan Subramanian

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Linear measures such as cross-correlation, coherence, and directed transfer functions have previously been applied to investigate the functional connectivity between brain regions. However, such methods do not account for nonlinear interactions between the signals. Separately, dopaminergic cell transplants have been shown to provide symptomatic amelioration and partial electrophysiological normalization of aberrant basal ganglia firing patterns in Parkinson's Disease. However, the precise extent and mechanisms of basal ganglia electrophysiological normalization have remained unclear. In this experiment we computed the transfer entropy between electroencephalograms (EEGs) and basal ganglia local field potentials (LFPs) from urethane-anesthetized rats, in order to investigate both linear and nonlinear interactions. We used the 6-hydroxy-dopamine lesioned medial forebrain bundle hemiparkinsonian (HP) rat model, and recorded from the substantia nigra and subthalamic nucleus of normal rats, HP rats, and HP rats with murine fetal ventral mesencephalic cell transplants, looking separately at slow wave EEG epochs versus global activation epochs. We found that both the crosscorrelation and the transfer entropy between the motor cortical EEG and basal ganglia LFPs was increased in the HP group (p<0.05) and returned to normal levels in the grafted group, in most nuclei and conditions. However, the transfer entropy more robustly showed the difference between the groups. Our findings indicate that transfer entropy is a sensitive tool for nonlinear inter-nucleic functional connectivity analyses, and demonstrate the novel restorative ability of dopaminergic grafts for the parkinsonian basal ganglia electrophysiology.

Original languageEnglish (US)
Title of host publication2012 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2012
DOIs
StatePublished - Dec 1 2012
Event2012 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2012 - New York, NY, United States
Duration: Dec 1 2012Dec 1 2012

Other

Other2012 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2012
CountryUnited States
CityNew York, NY
Period12/1/1212/1/12

Fingerprint

Electrophysiology
Rats
Entropy
Electroencephalography
Transplants
Bioelectric potentials
Grafts
Transfer functions
Brain
Chemical activation
Experiments

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering

Cite this

Gilmour, T. P., Lagoa, C. M., Jenkins, W. K., Rao, A. N., Berk, M. A., Venkiteswaran, K., & Subramanian, T. (2012). Transfer entropy between cortical and basal ganglia electrophysiology. In 2012 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2012 [6469453] https://doi.org/10.1109/SPMB.2012.6469453
Gilmour, Timothy P. ; Lagoa, Constantino Manuel ; Jenkins, William Kenneth ; Rao, Anand N. ; Berk, Matthew A. ; Venkiteswaran, Kala ; Subramanian, Thyagarajan. / Transfer entropy between cortical and basal ganglia electrophysiology. 2012 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2012. 2012.
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Gilmour, TP, Lagoa, CM, Jenkins, WK, Rao, AN, Berk, MA, Venkiteswaran, K & Subramanian, T 2012, Transfer entropy between cortical and basal ganglia electrophysiology. in 2012 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2012., 6469453, 2012 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2012, New York, NY, United States, 12/1/12. https://doi.org/10.1109/SPMB.2012.6469453

Transfer entropy between cortical and basal ganglia electrophysiology. / Gilmour, Timothy P.; Lagoa, Constantino Manuel; Jenkins, William Kenneth; Rao, Anand N.; Berk, Matthew A.; Venkiteswaran, Kala; Subramanian, Thyagarajan.

2012 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2012. 2012. 6469453.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Gilmour TP, Lagoa CM, Jenkins WK, Rao AN, Berk MA, Venkiteswaran K et al. Transfer entropy between cortical and basal ganglia electrophysiology. In 2012 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2012. 2012. 6469453 https://doi.org/10.1109/SPMB.2012.6469453