Transformed Follicular Lymphoma (TFL) predicts outcome in advanced endometrial cancer

Senn Wakahashi, Fumi Kawakami, Kanako Wakahashi, Kentaro Minagawa, Keitaro Matsuo, Yoshio Katayama, Hideto Yamada, Toshimitsu Matsui, Tamotsu Sudo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Transformed follicular lymphoma (TFL, ZC3H12D) was identified as a candidate tumor suppressor gene that contributes to cell-cycle arrest through regulation of Rb phosphorylation, but the clinical impact of TFL is unknown. The goal of this study was to evaluate the prognostic significance of TFL expression in advanced endometrial cancer. Methods: Tissue samples were obtained from 103 patients with Federation Internationale des Gynaecologistes et Obstetristes stage III–IV endometrial cancer. Associations between TFL expression and outcomes were evaluated using the Kaplan–Meier method and multivariate Cox proportional hazards regression models. Results: There were 24 TFL-low cases (23.3%) and the 10-year progression-free survival (PFS) and overall survival (OS) in these cases were lower than those for patients with normal TFL expression in univariate analysis (PFS, P ¼ 0.003; OS, P ¼ 0.106). In multivariate analysis, TFL status was a significant predictor for PFS [HR ¼ 2.76; 95% confidence interval (CI), 1.45–5.28; P ¼ 0.002] and OS (HR ¼ 1.94; 95% CI, 0.91–4.11; P ¼ 0.085), adjusted for covariates. The TFL gene maps to human chromosome 6q25.1, where estrogen receptor alpha (ERa) gene ESR1 is also located. Lack of ERa expression is a poor prognostic factor in early endometrial cancer. Among 41 ERa-low patients, 10-year PFS was significantly lower in 15 TFL-low cases (univariate analysis, P ¼ 0.055; multivariate analysis, HR ¼ 4.70; 95% CI, 1.68–13.20; P ¼ 0.003). Conclusions: We identified TFL as a strong independent prognostic factor, regardless of ERa status. Impact: An investigation of the mechanism underlying tumor suppression by TFL may lead to new therapies for patients with advanced endometrial cancer.

Original languageEnglish (US)
Pages (from-to)963-969
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume27
Issue number8
DOIs
StatePublished - Aug 2018

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

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