Transforming growth factor-beta and suppression of carcinogenesis.

M. B. Sporn, A. B. Roberts, L. M. Wakefield, Adam Bleier Glick, D. Danielpour

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Transforming growth factor-beta (TGF-beta) plays an important role in controlling proliferation or differentiation in almost all epithelial tissues. The pathophysiology of TGF-beta during carcinogenesis is now an important area of investigation, since it appears that as the process of carcinogenesis progresses, epithelial cells often become refractory to the growth-regulatory actions of TGF-beta. In this article we consider the possible cellular and molecular bases for this phenomenon, and then discuss some pharmacological approaches to enhancing the synthesis or activity of TGF-beta. These approaches may provide new modalities for prevention of carcinogenesis, if they can be applied during the early stages of the disease process, before cells become refractory. We give particular attention to tamoxifen and retinoic acid, since it has been shown that these agents, which are of known efficacy for prevention of cancer, can markedly enhance the secretion of specific isotypes of TGF-beta by several types of cells.

Original languageEnglish (US)
Pages (from-to)259-266
Number of pages8
JournalPrincess Takamatsu symposia
Volume20
StatePublished - Jan 1 1989

Fingerprint

Transforming Growth Factor beta
Carcinogenesis
Tretinoin
Epithelium
Epithelial Cells
Pharmacology
Growth
Neoplasms

Cite this

Sporn, M. B., Roberts, A. B., Wakefield, L. M., Glick, A. B., & Danielpour, D. (1989). Transforming growth factor-beta and suppression of carcinogenesis. Princess Takamatsu symposia, 20, 259-266.
Sporn, M. B. ; Roberts, A. B. ; Wakefield, L. M. ; Glick, Adam Bleier ; Danielpour, D. / Transforming growth factor-beta and suppression of carcinogenesis. In: Princess Takamatsu symposia. 1989 ; Vol. 20. pp. 259-266.
@article{81168684db6e4011bffaf670b340bd85,
title = "Transforming growth factor-beta and suppression of carcinogenesis.",
abstract = "Transforming growth factor-beta (TGF-beta) plays an important role in controlling proliferation or differentiation in almost all epithelial tissues. The pathophysiology of TGF-beta during carcinogenesis is now an important area of investigation, since it appears that as the process of carcinogenesis progresses, epithelial cells often become refractory to the growth-regulatory actions of TGF-beta. In this article we consider the possible cellular and molecular bases for this phenomenon, and then discuss some pharmacological approaches to enhancing the synthesis or activity of TGF-beta. These approaches may provide new modalities for prevention of carcinogenesis, if they can be applied during the early stages of the disease process, before cells become refractory. We give particular attention to tamoxifen and retinoic acid, since it has been shown that these agents, which are of known efficacy for prevention of cancer, can markedly enhance the secretion of specific isotypes of TGF-beta by several types of cells.",
author = "Sporn, {M. B.} and Roberts, {A. B.} and Wakefield, {L. M.} and Glick, {Adam Bleier} and D. Danielpour",
year = "1989",
month = "1",
day = "1",
language = "English (US)",
volume = "20",
pages = "259--266",
journal = "Princess Takamatsu symposia",

}

Sporn, MB, Roberts, AB, Wakefield, LM, Glick, AB & Danielpour, D 1989, 'Transforming growth factor-beta and suppression of carcinogenesis.', Princess Takamatsu symposia, vol. 20, pp. 259-266.

Transforming growth factor-beta and suppression of carcinogenesis. / Sporn, M. B.; Roberts, A. B.; Wakefield, L. M.; Glick, Adam Bleier; Danielpour, D.

In: Princess Takamatsu symposia, Vol. 20, 01.01.1989, p. 259-266.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Transforming growth factor-beta and suppression of carcinogenesis.

AU - Sporn, M. B.

AU - Roberts, A. B.

AU - Wakefield, L. M.

AU - Glick, Adam Bleier

AU - Danielpour, D.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Transforming growth factor-beta (TGF-beta) plays an important role in controlling proliferation or differentiation in almost all epithelial tissues. The pathophysiology of TGF-beta during carcinogenesis is now an important area of investigation, since it appears that as the process of carcinogenesis progresses, epithelial cells often become refractory to the growth-regulatory actions of TGF-beta. In this article we consider the possible cellular and molecular bases for this phenomenon, and then discuss some pharmacological approaches to enhancing the synthesis or activity of TGF-beta. These approaches may provide new modalities for prevention of carcinogenesis, if they can be applied during the early stages of the disease process, before cells become refractory. We give particular attention to tamoxifen and retinoic acid, since it has been shown that these agents, which are of known efficacy for prevention of cancer, can markedly enhance the secretion of specific isotypes of TGF-beta by several types of cells.

AB - Transforming growth factor-beta (TGF-beta) plays an important role in controlling proliferation or differentiation in almost all epithelial tissues. The pathophysiology of TGF-beta during carcinogenesis is now an important area of investigation, since it appears that as the process of carcinogenesis progresses, epithelial cells often become refractory to the growth-regulatory actions of TGF-beta. In this article we consider the possible cellular and molecular bases for this phenomenon, and then discuss some pharmacological approaches to enhancing the synthesis or activity of TGF-beta. These approaches may provide new modalities for prevention of carcinogenesis, if they can be applied during the early stages of the disease process, before cells become refractory. We give particular attention to tamoxifen and retinoic acid, since it has been shown that these agents, which are of known efficacy for prevention of cancer, can markedly enhance the secretion of specific isotypes of TGF-beta by several types of cells.

UR - http://www.scopus.com/inward/record.url?scp=0024893608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024893608&partnerID=8YFLogxK

M3 - Review article

C2 - 2562184

AN - SCOPUS:0024893608

VL - 20

SP - 259

EP - 266

JO - Princess Takamatsu symposia

JF - Princess Takamatsu symposia

ER -

Sporn MB, Roberts AB, Wakefield LM, Glick AB, Danielpour D. Transforming growth factor-beta and suppression of carcinogenesis. Princess Takamatsu symposia. 1989 Jan 1;20:259-266.