Transforming growth factors-α and -β1 levels in plasma and effusions from patients with cancer or hematologic malignancies

L. M. Witters, H. Al-Mondhiry, Y. L. Matthews, R. P. Walker, B. C. Langton, J. R. Dasch, A. Lipton

Research output: Contribution to journalArticlepeer-review

Abstract

Transforming growth factors-α and -β1 are thought to play a role in carcinogenesis. Using a sandwich linked immunosorbent assay, we have measured TGF-α and -β1 levels in malignant human plasma and effusions. TGF-α and -β1 plasma levels were not significantly different among normal volunteers, patients with solid tumors, and patients with hematologic malignancies (TGF-α, p = 0.225; TGF-β1, p = 0.354). Statistically significant differences were also not found in levels between malignant and non-malignant effusions (TGF-α, p = 0.327; TGF-β1, p = 0.095). However, a trend for the majority of elevated TGF-α or TGF-β1 levels to be in malignant effusions warrants further studies with larger numbers of samples.

Original languageEnglish (US)
Pages (from-to)943-950
Number of pages8
JournalInternational journal of oncology
Volume4
Issue number4
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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