Transforming growth factors released from Kirsten sarcoma virus transformed cells do not compete for epidermal growth factor membrane receptors

Chu Chang Chua, Deborah Geiman, Roger Ladda

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Kirsten murine sarcoma virus (KiMSV)‐transformed rat kidney cells (KNRK) release small polypeptides (M, 12,500–15,300) into the culture medium that are capable of stimulating normal rat kidney cells (NRK) to form colonies in soft agar. The transforming growth factors (TGFs) did not compete with epidermal growth factor (EGF) for its receptor and did not induce specific phosphorylation of EGF receptor on NRK cell membranes. These properties differ from the TGFs isolated by other investigators. Our data further establish the heterogeneity of the materials produced by transformed cells that induce transformation‐specific changes in normal cells.

Original languageEnglish (US)
Pages (from-to)116-122
Number of pages7
JournalJournal of Cellular Physiology
Volume117
Issue number1
DOIs
StatePublished - Jan 1 1983

Fingerprint

Kirsten murine sarcoma virus
Transforming Growth Factors
Viruses
Epidermal Growth Factor
Rats
Membranes
Epidermal Growth Factor Receptor
Phosphorylation
Kidney
Cell membranes
Agar
Culture Media
Peptides
Research Personnel
Cell Membrane
ErbB Receptors

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

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Transforming growth factors released from Kirsten sarcoma virus transformed cells do not compete for epidermal growth factor membrane receptors. / Chua, Chu Chang; Geiman, Deborah; Ladda, Roger.

In: Journal of Cellular Physiology, Vol. 117, No. 1, 01.01.1983, p. 116-122.

Research output: Contribution to journalArticle

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