Transforming growth factors released from Kirsten sarcoma virus transformed cells do not compete for epidermal growth factor membrane receptors

Chu Chang Chua, Deborah Geiman, Roger L. Ladda

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Kirsten murine sarcoma virus (KiMSV)‐transformed rat kidney cells (KNRK) release small polypeptides (M, 12,500–15,300) into the culture medium that are capable of stimulating normal rat kidney cells (NRK) to form colonies in soft agar. The transforming growth factors (TGFs) did not compete with epidermal growth factor (EGF) for its receptor and did not induce specific phosphorylation of EGF receptor on NRK cell membranes. These properties differ from the TGFs isolated by other investigators. Our data further establish the heterogeneity of the materials produced by transformed cells that induce transformation‐specific changes in normal cells.

Original languageEnglish (US)
Pages (from-to)116-122
Number of pages7
JournalJournal of Cellular Physiology
Volume117
Issue number1
DOIs
StatePublished - Oct 1983

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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