Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation

Fengyang Lei, Jianyong Song, Rizwanul Haque, Xiaofang Xiong, Deyu Fang, Yuzhang Wu, Susanne M.A. Lens, Michael Croft, Jianxun Song

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Survivin, an inhibitor of apoptosis family molecule, has been proposed as a crucial intermediate in the signaling pathways leading to T-cell development, proliferation, and expansion. However, the importance of survivin to T-cell-driven inflammatory responses has not been demonstrated. Here, we show that survivin transgenic mice exhibit an increased antigen-driven Th2 lung inflammation and that constitutive expression of survivin reversed the defective lung inflammation even in the absence of OX40 costimulation. We found that OX40-deficient mice were compromised in generating Th2 cells, airway eosinophilia, and IgE responses. In contrast, OX40-deficient/survivin transgenic mice generated normal Th2 responses and exhibited strong lung inflammation. These results suggest that OX40 costimulation crucially engages survivin during antigen-mediated Th2 responses. These findings also promote the notion that OX40 costimulation regulates allergic responses or lung inflammation by targeting survivin thereby enhancing T-cell proliferation and resulting in more differentiated Th2 cells in the allergic inflammatory response.

Original languageEnglish (US)
Pages (from-to)1914-1924
Number of pages11
JournalEuropean Journal of Immunology
Volume43
Issue number7
DOIs
StatePublished - Jul 1 2013

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Pneumonia
Inflammation
Th2 Cells
T-Lymphocytes
Transgenic Mice
Cell Proliferation
Antigens
Eosinophilia
Immunoglobulin E
Apoptosis

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Lei, Fengyang ; Song, Jianyong ; Haque, Rizwanul ; Xiong, Xiaofang ; Fang, Deyu ; Wu, Yuzhang ; Lens, Susanne M.A. ; Croft, Michael ; Song, Jianxun. / Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. In: European Journal of Immunology. 2013 ; Vol. 43, No. 7. pp. 1914-1924.
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abstract = "Survivin, an inhibitor of apoptosis family molecule, has been proposed as a crucial intermediate in the signaling pathways leading to T-cell development, proliferation, and expansion. However, the importance of survivin to T-cell-driven inflammatory responses has not been demonstrated. Here, we show that survivin transgenic mice exhibit an increased antigen-driven Th2 lung inflammation and that constitutive expression of survivin reversed the defective lung inflammation even in the absence of OX40 costimulation. We found that OX40-deficient mice were compromised in generating Th2 cells, airway eosinophilia, and IgE responses. In contrast, OX40-deficient/survivin transgenic mice generated normal Th2 responses and exhibited strong lung inflammation. These results suggest that OX40 costimulation crucially engages survivin during antigen-mediated Th2 responses. These findings also promote the notion that OX40 costimulation regulates allergic responses or lung inflammation by targeting survivin thereby enhancing T-cell proliferation and resulting in more differentiated Th2 cells in the allergic inflammatory response.",
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Lei, F, Song, J, Haque, R, Xiong, X, Fang, D, Wu, Y, Lens, SMA, Croft, M & Song, J 2013, 'Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation', European Journal of Immunology, vol. 43, no. 7, pp. 1914-1924. https://doi.org/10.1002/eji.201243081

Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. / Lei, Fengyang; Song, Jianyong; Haque, Rizwanul; Xiong, Xiaofang; Fang, Deyu; Wu, Yuzhang; Lens, Susanne M.A.; Croft, Michael; Song, Jianxun.

In: European Journal of Immunology, Vol. 43, No. 7, 01.07.2013, p. 1914-1924.

Research output: Contribution to journalArticle

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AU - Lei, Fengyang

AU - Song, Jianyong

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AU - Fang, Deyu

AU - Wu, Yuzhang

AU - Lens, Susanne M.A.

AU - Croft, Michael

AU - Song, Jianxun

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