Transgenic mice expressing the thymus leukemia antigen fail to control cutaneous herpes simplex virus infection

Padmanee Sharma, Colena A. Johnson, Robert H. Bonneau, C. Max Lang, Michael J. Chorney

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

TL-transgenic mice expressing the thymus leukemia antigen demonstrate a lack of viral clearance following cutaneous HSV infection of the footpad. In this study, both uninfected and HSV-infected TL-transgenic mice demonstrate increased concentrations of IL-4 as well as decreased concentrations of IFN-γ which may possibly underlie the impairment of viral clearance, Furthermore, lymphocytes from HSV-infected nontransgenic mice, adoptively transferred into HSV-infected TL-transgenic mice, promoted viral clearance and led to an increase in IFN-γ production. Transgenic mice which were subcutaneously injected with IFN-γ in the right footpad were also capable of clearing the viral challenge; however, clearance was restricted solely to the right footpad, These studies support the possibility of perturbations in the immune system of TL-transgenic mice and effectively demonstrate the utility of this model system in the study of HSV clearance, persistence, and potential spontaneous reactivation. Moreover, the TL-transgenic animals may provide a useful model system for additional studies requiring a host system skewed toward a Th2 phenotype.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalCellular Immunology
Volume174
Issue number1
DOIs
StatePublished - Nov 25 1996

All Science Journal Classification (ASJC) codes

  • Immunology

Fingerprint Dive into the research topics of 'Transgenic mice expressing the thymus leukemia antigen fail to control cutaneous herpes simplex virus infection'. Together they form a unique fingerprint.

  • Cite this