Transgenic rabbit models for studying human cardiovascular diseases

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Cardiovascular diseases involve the heart or blood vessels and remain a leading cause of morbidity and mortality in developed countries. A variety of animal models have been used to study cardiovascular diseases and have contributed to our understanding of their pathophysiology and treatment. However, mutations or abnormal expression of specific genes play important roles in the pathophysiology of some heart diseases, for which a closely similar animal model often is not naturally available. With the advent of techniques for specific genomic modification, several transgenic and knockout mouse models have been developed for cardiovascular conditions that result from spontaneous mutations. However, mouse and human heart show marked electrophysiologic differences. In addition, cardiac studies in mouse models are extremely difficult because of their small heart size and fast heart rate. Therefore, larger genetically engineered animal models are needed to overcome the limitations of the mouse models. This review summarizes the transgenic rabbit models that have been developed to study cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)472-479
Number of pages8
JournalComparative Medicine
Volume62
Issue number6
StatePublished - Dec 2012

Fingerprint

cardiovascular diseases
Cardiovascular Diseases
Animal Models
animal models
rabbits
genetically modified organisms
Rabbits
Mutation
Genetically Modified Animals
heart
Animals
pathophysiology
Developed Countries
Knockout Mice
Transgenic Mice
Blood Vessels
Heart Diseases
Heart Rate
Morbidity
mutation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

@article{c69d10790b6f4841ab44912c7f3e6f72,
title = "Transgenic rabbit models for studying human cardiovascular diseases",
abstract = "Cardiovascular diseases involve the heart or blood vessels and remain a leading cause of morbidity and mortality in developed countries. A variety of animal models have been used to study cardiovascular diseases and have contributed to our understanding of their pathophysiology and treatment. However, mutations or abnormal expression of specific genes play important roles in the pathophysiology of some heart diseases, for which a closely similar animal model often is not naturally available. With the advent of techniques for specific genomic modification, several transgenic and knockout mouse models have been developed for cardiovascular conditions that result from spontaneous mutations. However, mouse and human heart show marked electrophysiologic differences. In addition, cardiac studies in mouse models are extremely difficult because of their small heart size and fast heart rate. Therefore, larger genetically engineered animal models are needed to overcome the limitations of the mouse models. This review summarizes the transgenic rabbit models that have been developed to study cardiovascular diseases.",
author = "Xuwen Peng",
year = "2012",
month = "12",
language = "English (US)",
volume = "62",
pages = "472--479",
journal = "Comparative Medicine",
issn = "1532-0820",
publisher = "American Association for Laboratory Animal Science",
number = "6",

}

Transgenic rabbit models for studying human cardiovascular diseases. / Peng, Xuwen.

In: Comparative Medicine, Vol. 62, No. 6, 12.2012, p. 472-479.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Transgenic rabbit models for studying human cardiovascular diseases

AU - Peng, Xuwen

PY - 2012/12

Y1 - 2012/12

N2 - Cardiovascular diseases involve the heart or blood vessels and remain a leading cause of morbidity and mortality in developed countries. A variety of animal models have been used to study cardiovascular diseases and have contributed to our understanding of their pathophysiology and treatment. However, mutations or abnormal expression of specific genes play important roles in the pathophysiology of some heart diseases, for which a closely similar animal model often is not naturally available. With the advent of techniques for specific genomic modification, several transgenic and knockout mouse models have been developed for cardiovascular conditions that result from spontaneous mutations. However, mouse and human heart show marked electrophysiologic differences. In addition, cardiac studies in mouse models are extremely difficult because of their small heart size and fast heart rate. Therefore, larger genetically engineered animal models are needed to overcome the limitations of the mouse models. This review summarizes the transgenic rabbit models that have been developed to study cardiovascular diseases.

AB - Cardiovascular diseases involve the heart or blood vessels and remain a leading cause of morbidity and mortality in developed countries. A variety of animal models have been used to study cardiovascular diseases and have contributed to our understanding of their pathophysiology and treatment. However, mutations or abnormal expression of specific genes play important roles in the pathophysiology of some heart diseases, for which a closely similar animal model often is not naturally available. With the advent of techniques for specific genomic modification, several transgenic and knockout mouse models have been developed for cardiovascular conditions that result from spontaneous mutations. However, mouse and human heart show marked electrophysiologic differences. In addition, cardiac studies in mouse models are extremely difficult because of their small heart size and fast heart rate. Therefore, larger genetically engineered animal models are needed to overcome the limitations of the mouse models. This review summarizes the transgenic rabbit models that have been developed to study cardiovascular diseases.

UR - http://www.scopus.com/inward/record.url?scp=84876219182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876219182&partnerID=8YFLogxK

M3 - Review article

C2 - 23561880

AN - SCOPUS:84876219182

VL - 62

SP - 472

EP - 479

JO - Comparative Medicine

JF - Comparative Medicine

SN - 1532-0820

IS - 6

ER -