Transient Fourier holography with bacteriorhodopsin films for breast cancer diagnostics

Devulapalli Rao, Sri-Rajasekhar Kothapalli, Pengfei Wu, Chandra Yelleswarapu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

X-ray mammography is the current gold standard for breast cancer screening. Microcalcifications and other features which are helpful to the radiologist for early diagnostics are often buried in the noise generated by the surrounding dense tissue. So image processing techniques are required to enhance these important features to improve the sensitivity of detection. An innovative technique is demonstrated for recording a hologram of the mammogram. It is recorded on a thin polymer film of Bacteriorhodopsin (bR) as photo induced isomerization grating containing the interference pattern between the object beam containing the Fourier spatial frequency components of the mammogram and a reference beam. The hologram contains all the enhanced features of the mammogram. A significant innovation of the technique is that the enhanced components in the processed image can be viewed by the radiologist in time scale. A technician can record the movie and when the radiologist looks at the movie at his convenience, freezing the frame as and when desired, he would see the microcalcifications as the brightest and last long in time. He would also observe lesions with intensity decreasing as their size increases. The same bR film can be used repeatedly for recording holograms with different mammograms. The technique is versatile and a different frequency band can be chosen to be optimized by changing the reference beam intensity. The experimental arrangement can be used for mammograms in screen film or digital format.

Original languageEnglish (US)
Title of host publicationBioinspired, Biointegrated, Bioengineered Photonic Devices
DOIs
StatePublished - May 30 2013
EventBioinspired, Biointegrated, Bioengineered Photonic Devices - San Francisco, CA, United States
Duration: Feb 2 2013Feb 3 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8598
ISSN (Print)1605-7422

Other

OtherBioinspired, Biointegrated, Bioengineered Photonic Devices
CountryUnited States
CitySan Francisco, CA
Period2/2/132/3/13

Fingerprint

Holography
Bacteriorhodopsins
Holograms
breast
holography
Calcinosis
cancer
Motion Pictures
Breast Neoplasms
recording
Mammography
Isomerization
Early Detection of Cancer
Polymer films
Freezing
lesions
freezing
isomerization
Frequency bands
format

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Rao, D., Kothapalli, S-R., Wu, P., & Yelleswarapu, C. (2013). Transient Fourier holography with bacteriorhodopsin films for breast cancer diagnostics. In Bioinspired, Biointegrated, Bioengineered Photonic Devices [85980K] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8598). https://doi.org/10.1117/12.2020227
Rao, Devulapalli ; Kothapalli, Sri-Rajasekhar ; Wu, Pengfei ; Yelleswarapu, Chandra. / Transient Fourier holography with bacteriorhodopsin films for breast cancer diagnostics. Bioinspired, Biointegrated, Bioengineered Photonic Devices. 2013. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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Rao, D, Kothapalli, S-R, Wu, P & Yelleswarapu, C 2013, Transient Fourier holography with bacteriorhodopsin films for breast cancer diagnostics. in Bioinspired, Biointegrated, Bioengineered Photonic Devices., 85980K, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8598, Bioinspired, Biointegrated, Bioengineered Photonic Devices, San Francisco, CA, United States, 2/2/13. https://doi.org/10.1117/12.2020227

Transient Fourier holography with bacteriorhodopsin films for breast cancer diagnostics. / Rao, Devulapalli; Kothapalli, Sri-Rajasekhar; Wu, Pengfei; Yelleswarapu, Chandra.

Bioinspired, Biointegrated, Bioengineered Photonic Devices. 2013. 85980K (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8598).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Rao D, Kothapalli S-R, Wu P, Yelleswarapu C. Transient Fourier holography with bacteriorhodopsin films for breast cancer diagnostics. In Bioinspired, Biointegrated, Bioengineered Photonic Devices. 2013. 85980K. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2020227