Transient receptor potential canonical 7 (TRPC7), a calcium (Ca2+) permeable non-selective cation channel

Xuexin Zhang, Amy M. Spinelli, Timothy Masiello, Mohamed Trebak

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Transient receptor potential canonical subfamily, member 7 (TRPC7) is the most recently identified member of the TRPC family of Ca2+ -permeable nonselective cation channels. The gene encoding the TRPC7 channel plasma membrane protein was first cloned from mouse brain. TRPC7 mRNA and protein have been detected in cell types derived from multiple organ systems from various species including humans. Gq -coupled protein receptor activation is the predominant mode of TRPC7 activation. Lipid metabolites involved in the phospholipase C (PLC) signaling pathway, including diacylglycerol (DAG) and its precursor the phosphatidylinositol- 4,5-bisphosphate (PIP2), have been shown to be direct regulators of TRPC7 channel. TRPC7 channels have been linked to the regulation of various cellular functions however, the depth of our understanding of TRPC7 channel function and regulation is limited in comparison to other TRP channel family members. This review takes a historical look at our current knowledge of TRPC7 mechanisms of activation and its role in cellular physiology and pathophysiology.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages251-264
Number of pages14
DOIs
StatePublished - May 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume898
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Zhang, X., Spinelli, A. M., Masiello, T., & Trebak, M. (2016). Transient receptor potential canonical 7 (TRPC7), a calcium (Ca2+) permeable non-selective cation channel. In Advances in Experimental Medicine and Biology (pp. 251-264). (Advances in Experimental Medicine and Biology; Vol. 898). Springer New York LLC. https://doi.org/10.1007/978-3-319-26974-0_11