Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma

Nelson Shu-Sang Yee, Weiqiang Zhou, Minsun Lee

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The roles of transient receptor potential (TRP) cation channels in pancreatic tumorigenesis are essentially unknown. Here, we focus on the TRP melastatin-subfamily (TRPM) members. Expression of the thermally regulated transmembrane Ca2+-permeable channel TRPM8 is consistently up-regulated in human pancreatic adenocarcinoma cell lines and tissues. TRPM8-deficient pancreatic cancer cells have reduced ability of proliferation and cell cycle progression with elevated levels of cyclin-dependent kinase inhibitors. These results indicate that TRPM8 is aberrantly over-expressed in pancreatic adenocarcinoma and required for cellular proliferation, and they support further investigation of the potential of TRPM8 as a clinical biomarker and therapeutic target in pancreatic adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalCancer Letters
Volume297
Issue number1
DOIs
StatePublished - Nov 1 2010

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Transient Receptor Potential Channels
Adenocarcinoma
Cell Proliferation
Cyclin-Dependent Kinases
Pancreatic Neoplasms
Cell Cycle
Carcinogenesis
Biomarkers
Cell Line
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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abstract = "The roles of transient receptor potential (TRP) cation channels in pancreatic tumorigenesis are essentially unknown. Here, we focus on the TRP melastatin-subfamily (TRPM) members. Expression of the thermally regulated transmembrane Ca2+-permeable channel TRPM8 is consistently up-regulated in human pancreatic adenocarcinoma cell lines and tissues. TRPM8-deficient pancreatic cancer cells have reduced ability of proliferation and cell cycle progression with elevated levels of cyclin-dependent kinase inhibitors. These results indicate that TRPM8 is aberrantly over-expressed in pancreatic adenocarcinoma and required for cellular proliferation, and they support further investigation of the potential of TRPM8 as a clinical biomarker and therapeutic target in pancreatic adenocarcinoma.",
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Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma. / Yee, Nelson Shu-Sang; Zhou, Weiqiang; Lee, Minsun.

In: Cancer Letters, Vol. 297, No. 1, 01.11.2010, p. 49-55.

Research output: Contribution to journalArticle

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