Translating basic science to improve pharmacotherapy for nicotine dependence

Jennifer Phillips, Steven Siegel, Alexandra Shields, Freda Patterson, Thomas Gould, Andrew Strasser, Riju Ray, Angela Pinto, Janet Audrain-McGovern, Margaret Rukstalis, Kenneth Perkins, Julie Blendy, Caryn Lerman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Nicotine dependence has a complex multifactorial etiology, underscoring the value of applying a transdisciplinary research model. The important goal of treating nicotine dependence can be realized by transdisciplinary research that translates discoveries in basic neuroscience, pharmacology, genetics, and behavioral science to develop new treatment models that can be translated readily into the clinic and community. As part of this special issue highlighting work at the Transdisciplinary Tobacco Use Research Centers (TTURCs), we describe transdisciplinary research at the University of Pennsylvania TTURC aimed at elucidating the neurobiological and genetic basis of nicotine dependence, the development of novel medications, and the translation of this research to practice.

Original languageEnglish (US)
Pages (from-to)583-598
Number of pages16
JournalNicotine and Tobacco Research
Issue numberSUPPL. 4
StatePublished - Dec 2007

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


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