Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A

A. M. Karinch, J. Floros

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Transcripts of human SP-A genes, SP-A1 and SP-A2, undergo alternative splicing of 5' untranslated-region exons. We reverse transcribed and amplified free cytoplasmic and polysome-bound RNA and showed that (a) all splice variants of both genes are translated in vivo, (b) the relative translatability of splice variants can differ among individuals, and (c) the relative levels of different SP-A splice variants differ among individuals.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalBiochemical Journal
Volume307
Issue number2
DOIs
StatePublished - 1995

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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