Translational control by RGS2

Chau H. Nguyen, Hong Ming, Peishen Zhao, Lynne Hugendubler, Robert Gros, Scot R. Kimball, Peter Chidiac

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The regulator of G protein signaling (RGS) proteins are a family of guanosine triphosphatase (GTPase)-accelerating proteins. We have discovered a novel function for RGS2 in the control of protein synthesis. RGS2 was found to bind to eIF2Bε (eukaryotic initiation factor 2B ε subunit) and inhibit the translation of messenger RNA (mRNA) into new protein. This effect was not observed for other RGS proteins tested. This novel function of RGS2 is distinct from its ability to regulate G protein-mediated signals and maps to a stretch of 37 amino acid residues within its conserved RGS domain. Moreover, RGS2 was capable of interfering with the eIF2-eIF2B GTPase cycle, which is a requisite step for the initiation of mRNA translation. Collectively, this study has identified a novel role for RGS2 in the control of protein synthesis that is independent of its established RGS domain function.

Original languageEnglish (US)
Pages (from-to)755-765
Number of pages11
JournalJournal of Cell Biology
Volume186
Issue number5
DOIs
StatePublished - Sep 7 2009

Fingerprint

Eukaryotic Initiation Factor-2B
RGS Proteins
GTP-Binding Proteins
Guanosine
Proteins
Messenger RNA
Amino Acids
Protein Domains

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

Nguyen, C. H., Ming, H., Zhao, P., Hugendubler, L., Gros, R., Kimball, S. R., & Chidiac, P. (2009). Translational control by RGS2. Journal of Cell Biology, 186(5), 755-765. https://doi.org/10.1083/jcb.200811058
Nguyen, Chau H. ; Ming, Hong ; Zhao, Peishen ; Hugendubler, Lynne ; Gros, Robert ; Kimball, Scot R. ; Chidiac, Peter. / Translational control by RGS2. In: Journal of Cell Biology. 2009 ; Vol. 186, No. 5. pp. 755-765.
@article{2b491300dd3942ada500a9f53244dbc2,
title = "Translational control by RGS2",
abstract = "The regulator of G protein signaling (RGS) proteins are a family of guanosine triphosphatase (GTPase)-accelerating proteins. We have discovered a novel function for RGS2 in the control of protein synthesis. RGS2 was found to bind to eIF2Bε (eukaryotic initiation factor 2B ε subunit) and inhibit the translation of messenger RNA (mRNA) into new protein. This effect was not observed for other RGS proteins tested. This novel function of RGS2 is distinct from its ability to regulate G protein-mediated signals and maps to a stretch of 37 amino acid residues within its conserved RGS domain. Moreover, RGS2 was capable of interfering with the eIF2-eIF2B GTPase cycle, which is a requisite step for the initiation of mRNA translation. Collectively, this study has identified a novel role for RGS2 in the control of protein synthesis that is independent of its established RGS domain function.",
author = "Nguyen, {Chau H.} and Hong Ming and Peishen Zhao and Lynne Hugendubler and Robert Gros and Kimball, {Scot R.} and Peter Chidiac",
year = "2009",
month = "9",
day = "7",
doi = "10.1083/jcb.200811058",
language = "English (US)",
volume = "186",
pages = "755--765",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "5",

}

Nguyen, CH, Ming, H, Zhao, P, Hugendubler, L, Gros, R, Kimball, SR & Chidiac, P 2009, 'Translational control by RGS2', Journal of Cell Biology, vol. 186, no. 5, pp. 755-765. https://doi.org/10.1083/jcb.200811058

Translational control by RGS2. / Nguyen, Chau H.; Ming, Hong; Zhao, Peishen; Hugendubler, Lynne; Gros, Robert; Kimball, Scot R.; Chidiac, Peter.

In: Journal of Cell Biology, Vol. 186, No. 5, 07.09.2009, p. 755-765.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Translational control by RGS2

AU - Nguyen, Chau H.

AU - Ming, Hong

AU - Zhao, Peishen

AU - Hugendubler, Lynne

AU - Gros, Robert

AU - Kimball, Scot R.

AU - Chidiac, Peter

PY - 2009/9/7

Y1 - 2009/9/7

N2 - The regulator of G protein signaling (RGS) proteins are a family of guanosine triphosphatase (GTPase)-accelerating proteins. We have discovered a novel function for RGS2 in the control of protein synthesis. RGS2 was found to bind to eIF2Bε (eukaryotic initiation factor 2B ε subunit) and inhibit the translation of messenger RNA (mRNA) into new protein. This effect was not observed for other RGS proteins tested. This novel function of RGS2 is distinct from its ability to regulate G protein-mediated signals and maps to a stretch of 37 amino acid residues within its conserved RGS domain. Moreover, RGS2 was capable of interfering with the eIF2-eIF2B GTPase cycle, which is a requisite step for the initiation of mRNA translation. Collectively, this study has identified a novel role for RGS2 in the control of protein synthesis that is independent of its established RGS domain function.

AB - The regulator of G protein signaling (RGS) proteins are a family of guanosine triphosphatase (GTPase)-accelerating proteins. We have discovered a novel function for RGS2 in the control of protein synthesis. RGS2 was found to bind to eIF2Bε (eukaryotic initiation factor 2B ε subunit) and inhibit the translation of messenger RNA (mRNA) into new protein. This effect was not observed for other RGS proteins tested. This novel function of RGS2 is distinct from its ability to regulate G protein-mediated signals and maps to a stretch of 37 amino acid residues within its conserved RGS domain. Moreover, RGS2 was capable of interfering with the eIF2-eIF2B GTPase cycle, which is a requisite step for the initiation of mRNA translation. Collectively, this study has identified a novel role for RGS2 in the control of protein synthesis that is independent of its established RGS domain function.

UR - http://www.scopus.com/inward/record.url?scp=69949131136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69949131136&partnerID=8YFLogxK

U2 - 10.1083/jcb.200811058

DO - 10.1083/jcb.200811058

M3 - Article

C2 - 19736320

AN - SCOPUS:69949131136

VL - 186

SP - 755

EP - 765

JO - Journal of Cell Biology

JF - Journal of Cell Biology

SN - 0021-9525

IS - 5

ER -

Nguyen CH, Ming H, Zhao P, Hugendubler L, Gros R, Kimball SR et al. Translational control by RGS2. Journal of Cell Biology. 2009 Sep 7;186(5):755-765. https://doi.org/10.1083/jcb.200811058