Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eif2

Bo Jhih Guan, Dawid Krokowski, Mithu Majumder, Christine L. Schmotzer, Scot R. Kimball, William C. Merrick, Antonis E. Koromilas, Maria Hatzoglou

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Background: Chronic ER stress suppresses mTORC1 activity. Results: mTORC1-mediated suppression of translation during chronic ER stress is independent of the stress-induced eIF2α- P/ATF4 signaling. Conclusion: The eIF2α-P/ATF4-induced network of amino acid transporters promotes protein synthesis in part by increasing mTORC1-mediated translational control. Significance: The eIF2α-P/ATF4/mTORC1 network controls protein synthesis rates during chronic ER stress and mediates the degree of stress response and survival outcomes.

Original languageEnglish (US)
Pages (from-to)12593-12611
Number of pages19
JournalJournal of Biological Chemistry
Volume289
Issue number18
DOIs
StatePublished - 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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