TY - JOUR
T1 - Translational MRI Volumetry with NeuroQuant
T2 - Effects of Version and Normative Data on Relationships with Memory Performance in Healthy Older Adults and Patients with Mild Cognitive Impairment
AU - Stelmokas, Julija
AU - Yassay, Lance
AU - Giordani, Bruno
AU - Dodge, Hiroko H.
AU - Dinov, Ivo D.
AU - Bhaumik, Arijit
AU - Sathian, K.
AU - Hampstead, Benjamin M.
N1 - Funding Information:
The manuscript does not represent the views of the Department of Veterans Affairs or the United States Government. This project was partially supported by VA Merit Review Award (IRX001534) and Career Development Award (B6366W), NIH/NIA funded Michigan Alzheimer’s Disease Center (5P30AG053760), NSF grants 1416953, 1023115, NIH grants P20 NR015331, U54 EB020406, P50 NS091856, P30 DK089503, and the Emory University Alzheimer’s Disease Research Center (2P50AG025688). The first author (JS) was supported by the VA Advanced Fellowship in Geriatrics at VA Ann Arbor Healthcare System. Results were presented at the 2017 annual meeting of the International Neuropsychological Society.
Publisher Copyright:
© 2017 - IOS Press and the authors. All rights reserved.
PY - 2017
Y1 - 2017
N2 - NeuroQuant (NQ) is a fully-automated program that overcomes several existing limitations in the clinical translation of MRI-derived volumetry. The current study characterized differences between the original (NQ1) and an updated NQ version (NQ2) by 1) replicating previously identified relationships between neuropsychological test performance and medial temporal lobe volumes, 2) evaluating the level of agreement between NQ versions, and 3) determining if the addition of NQ2 age-/sex-based z-scores hold greater clinical utility for prediction of memory impairment than standard percent of intracranial volume (% ICV) values. Sixty-seven healthy older adults and 65 mild cognitive impairment patients underwent structural MRI and completed cognitive testing, including the Immediate and Delayed Memory indices from the Repeatable Battery for the Assessment of Neuropsychological Status. Results generally replicated previous relationships between key medial temporal lobe regions and memory test performance, though comparison of NQ regions revealed statistically different values that were biased toward one version or the other depending on the region. NQ2 hippocampal z-scores explained additional variance in memory performance relative to % ICV values. Findings indicate that NQ1/2 medial temporal lobe volumes, especially age- and sex-based z-scores, hold clinical value, though caution is warranted when directly comparing volumes across NQ versions.
AB - NeuroQuant (NQ) is a fully-automated program that overcomes several existing limitations in the clinical translation of MRI-derived volumetry. The current study characterized differences between the original (NQ1) and an updated NQ version (NQ2) by 1) replicating previously identified relationships between neuropsychological test performance and medial temporal lobe volumes, 2) evaluating the level of agreement between NQ versions, and 3) determining if the addition of NQ2 age-/sex-based z-scores hold greater clinical utility for prediction of memory impairment than standard percent of intracranial volume (% ICV) values. Sixty-seven healthy older adults and 65 mild cognitive impairment patients underwent structural MRI and completed cognitive testing, including the Immediate and Delayed Memory indices from the Repeatable Battery for the Assessment of Neuropsychological Status. Results generally replicated previous relationships between key medial temporal lobe regions and memory test performance, though comparison of NQ regions revealed statistically different values that were biased toward one version or the other depending on the region. NQ2 hippocampal z-scores explained additional variance in memory performance relative to % ICV values. Findings indicate that NQ1/2 medial temporal lobe volumes, especially age- and sex-based z-scores, hold clinical value, though caution is warranted when directly comparing volumes across NQ versions.
UR - http://www.scopus.com/inward/record.url?scp=85033608900&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033608900&partnerID=8YFLogxK
U2 - 10.3233/JAD-170306
DO - 10.3233/JAD-170306
M3 - Article
C2 - 29060939
AN - SCOPUS:85033608900
VL - 60
SP - 1499
EP - 1510
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 4
ER -