Translational MRI Volumetry with NeuroQuant: Effects of Version and Normative Data on Relationships with Memory Performance in Healthy Older Adults and Patients with Mild Cognitive Impairment

Julija Stelmokas, Lance Yassay, Bruno Giordani, Hiroko H. Dodge, Ivo D. Dinov, Arijit Bhaumik, Krishnankutty Sathian, Benjamin M. Hampstead

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

NeuroQuant (NQ) is a fully-automated program that overcomes several existing limitations in the clinical translation of MRI-derived volumetry. The current study characterized differences between the original (NQ1) and an updated NQ version (NQ2) by 1) replicating previously identified relationships between neuropsychological test performance and medial temporal lobe volumes, 2) evaluating the level of agreement between NQ versions, and 3) determining if the addition of NQ2 age-/sex-based z-scores hold greater clinical utility for prediction of memory impairment than standard percent of intracranial volume (% ICV) values. Sixty-seven healthy older adults and 65 mild cognitive impairment patients underwent structural MRI and completed cognitive testing, including the Immediate and Delayed Memory indices from the Repeatable Battery for the Assessment of Neuropsychological Status. Results generally replicated previous relationships between key medial temporal lobe regions and memory test performance, though comparison of NQ regions revealed statistically different values that were biased toward one version or the other depending on the region. NQ2 hippocampal z-scores explained additional variance in memory performance relative to % ICV values. Findings indicate that NQ1/2 medial temporal lobe volumes, especially age- and sex-based z-scores, hold clinical value, though caution is warranted when directly comparing volumes across NQ versions.

Original languageEnglish (US)
Pages (from-to)1499-1510
Number of pages12
JournalJournal of Alzheimer's Disease
Volume60
Issue number4
DOIs
StatePublished - Jan 1 2017

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Temporal Lobe
Repression (Psychology)
Neuropsychological Tests
Short-Term Memory
Cognitive Dysfunction

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Stelmokas, Julija ; Yassay, Lance ; Giordani, Bruno ; Dodge, Hiroko H. ; Dinov, Ivo D. ; Bhaumik, Arijit ; Sathian, Krishnankutty ; Hampstead, Benjamin M. / Translational MRI Volumetry with NeuroQuant : Effects of Version and Normative Data on Relationships with Memory Performance in Healthy Older Adults and Patients with Mild Cognitive Impairment. In: Journal of Alzheimer's Disease. 2017 ; Vol. 60, No. 4. pp. 1499-1510.
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Translational MRI Volumetry with NeuroQuant : Effects of Version and Normative Data on Relationships with Memory Performance in Healthy Older Adults and Patients with Mild Cognitive Impairment. / Stelmokas, Julija; Yassay, Lance; Giordani, Bruno; Dodge, Hiroko H.; Dinov, Ivo D.; Bhaumik, Arijit; Sathian, Krishnankutty; Hampstead, Benjamin M.

In: Journal of Alzheimer's Disease, Vol. 60, No. 4, 01.01.2017, p. 1499-1510.

Research output: Contribution to journalArticle

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