Translational regulation during stage transitions in malaria parasites

Liwang Cui, Scott Eugene Lindner, Jun Miao

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The complicated life cycle of the malaria parasite involves a vertebrate host and a mosquito vector, and translational regulation plays a prominent role in orchestrating the developmental events in the two transition stages: gametocytes and sporozoites. Translational regulation is executed in both global and transcript-specific manners. Plasmodium uses a conserved mechanism involving phosphorylation of eIF2α to repress global protein synthesis during the latent period of sporozoite development in the mosquito salivary glands. Transcript-specific translational regulation is achieved by a network of RNA-binding proteins (RBPs), among which the Dhh1 RNA helicase DOZI and Puf family RBPs are by far the best studied in Plasmodium. While the DOZI complex defines a new P granule with a role in protecting certain gametocyte mRNAs from degradation, the Puf proteins appear to repress expression of mRNAs in both gametocytes and sporozoites. These examples underscore the significance of translational regulation in Plasmodium development.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume1342
Issue number1
DOIs
StatePublished - Apr 1 2015

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Sporozoites
RNA-Binding Proteins
Plasmodium
Malaria
Parasites
RNA Helicases
Messenger RNA
Phosphorylation
Life cycle
Proteins
RNA Stability
Salivary Glands
Life Cycle Stages
Culicidae
Degradation
Vertebrates
Parasite
Protein

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

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Translational regulation during stage transitions in malaria parasites. / Cui, Liwang; Lindner, Scott Eugene; Miao, Jun.

In: Annals of the New York Academy of Sciences, Vol. 1342, No. 1, 01.04.2015, p. 1-9.

Research output: Contribution to journalArticle

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