TY - JOUR
T1 - Transmission consequences of coinfection
T2 - cytokines writ large?
AU - Graham, Andrea L.
AU - Cattadori, Isabella M.
AU - Lloyd-Smith, James O.
AU - Ferrari, Matthew J.
AU - Bjørnstad, Ottar N.
PY - 2007/6/1
Y1 - 2007/6/1
N2 - Coinfection of a host by multiple parasite species is commonly observed and recent epidemiological work indicates that coinfection can enhance parasite transmission. This article proposes an immunoepidemiological framework to understand how within-host interactions during coinfection might affect between-host transmission. Cytokines, immune signalling molecules with a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way to simplify immunological complexity for this endeavour - focusing on cytokines offers analytical tractability without sacrificing realism. Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework.
AB - Coinfection of a host by multiple parasite species is commonly observed and recent epidemiological work indicates that coinfection can enhance parasite transmission. This article proposes an immunoepidemiological framework to understand how within-host interactions during coinfection might affect between-host transmission. Cytokines, immune signalling molecules with a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way to simplify immunological complexity for this endeavour - focusing on cytokines offers analytical tractability without sacrificing realism. Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework.
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U2 - 10.1016/j.pt.2007.04.005
DO - 10.1016/j.pt.2007.04.005
M3 - Review article
C2 - 17466597
AN - SCOPUS:34248633392
VL - 23
SP - 284
EP - 291
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 6
ER -