Transmission consequences of coinfection: cytokines writ large?

Andrea L. Graham; Isabella M. Cattadori; James O. Lloyd-Smith; Matthew J. Ferrari; Ottar N. Bjørnstad

doi:10.1016/j.pt.2007.04.005

Transmission consequences of coinfection: cytokines writ large?

Andrea L. Graham, Isabella M. Cattadori, James O. Lloyd-Smith, Matthew J. Ferrari, Ottar N. Bjørnstad

Research output: Contribution to journal › Review article › peer-review

94 Scopus citations

Abstract

Coinfection of a host by multiple parasite species is commonly observed and recent epidemiological work indicates that coinfection can enhance parasite transmission. This article proposes an immunoepidemiological framework to understand how within-host interactions during coinfection might affect between-host transmission. Cytokines, immune signalling molecules with a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way to simplify immunological complexity for this endeavour - focusing on cytokines offers analytical tractability without sacrificing realism. Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework.

Original language	English (US)
Pages (from-to)	284-291
Number of pages	8
Journal	Trends in Parasitology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.pt.2007.04.005
State	Published - Jun 1 2007

All Science Journal Classification (ASJC) codes

Parasitology
Infectious Diseases

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title = "Transmission consequences of coinfection: cytokines writ large?",

abstract = "Coinfection of a host by multiple parasite species is commonly observed and recent epidemiological work indicates that coinfection can enhance parasite transmission. This article proposes an immunoepidemiological framework to understand how within-host interactions during coinfection might affect between-host transmission. Cytokines, immune signalling molecules with a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way to simplify immunological complexity for this endeavour - focusing on cytokines offers analytical tractability without sacrificing realism. Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework.",

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T2 - cytokines writ large?

AU - Graham, Andrea L.

AU - Cattadori, Isabella M.

AU - Lloyd-Smith, James O.

AU - Ferrari, Matthew J.

AU - Bjørnstad, Ottar N.

PY - 2007/6/1

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N2 - Coinfection of a host by multiple parasite species is commonly observed and recent epidemiological work indicates that coinfection can enhance parasite transmission. This article proposes an immunoepidemiological framework to understand how within-host interactions during coinfection might affect between-host transmission. Cytokines, immune signalling molecules with a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way to simplify immunological complexity for this endeavour - focusing on cytokines offers analytical tractability without sacrificing realism. Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework.

AB - Coinfection of a host by multiple parasite species is commonly observed and recent epidemiological work indicates that coinfection can enhance parasite transmission. This article proposes an immunoepidemiological framework to understand how within-host interactions during coinfection might affect between-host transmission. Cytokines, immune signalling molecules with a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way to simplify immunological complexity for this endeavour - focusing on cytokines offers analytical tractability without sacrificing realism. Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework.

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JO - Trends in Parasitology

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